A viewpoint published in @JAMA_current with a cautionary take on direct pharmacologic tx: Treating #COVID19 Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/diX9COrT3G 2/
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @IDPharmacometrx: Excellent overview of the therapeutic misconception as it pertains to #COVID19
Excellent overview of the therapeutic misconception as it pertains to #COVID19
«By participating in an RCT, both patients and clinicians can benefit from the unique opportunity to directly contribute to the discovery of new therapies» https://t.co/S0fVcmoBBs
RT @MedecineLibre: @Echologiste @wargonm Article qui explique pourquoi il est extrêmement important et indispensable d'effectuer des essais…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
@Echologiste @wargonm Article qui explique pourquoi il est extrêmement important et indispensable d'effectuer des essais cliniques randomisés contrôlés lors des épidémies de maladies qui n'ont aucun traitement validé. https://t.co/S0fVcmoBBs
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @nandoaimar: Muy importante 👇 Ante la neurosis colectiva, no debemos perder el norte. Todos los tratamientos para el SARS-COV-2 tienen u…
RT @Ferchu_Ortiz: Couldn’t agree more @ERAEDTA @ESOTtransplant @HUS_uutisoi
RT @nandoaimar: Muy importante 👇 Ante la neurosis colectiva, no debemos perder el norte. Todos los tratamientos para el SARS-COV-2 tienen u…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @hadito13: عن المعضلة الاخلاقية في الدراسات عن العلاج.. هل من غير الاخلاقي مقارنة مجموعتين مع او بدون علاج لمعرفة اذا ما كان علاج ما فعا…
عن المعضلة الاخلاقية في الدراسات عن العلاج.. هل من غير الاخلاقي مقارنة مجموعتين مع او بدون علاج لمعرفة اذا ما كان علاج ما فعال؟ الرأي في هذا المقال هو لا. لاننا لا نعرف اذا كان هناك تأثير سلبي للعلاج ولاننا لحاجة لجواب للجائحة المقبلة #healthNerds
Para los que ( como yo) tienen dudas de cómo se genera evidencia en una pandemia: https://t.co/XEDyGawql3
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @ToshiAkima: This article is mandatory reading for all fellow clinician. That means YOU #COVID4MDs #FOAMcovid
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
Couldn’t agree more @ERAEDTA @ESOTtransplant @HUS_uutisoi
"Se o paciente morrer, foi por causa da doença. Se sobreviver, foi por causa do remédio". Uma explicação de como ainda não é possível validar medicamentos como a cloroquina.
RT @nandoaimar: Muy importante 👇 Ante la neurosis colectiva, no debemos perder el norte. Todos los tratamientos para el SARS-COV-2 tienen u…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the dream lives on! One day the right modulatory agent will be found. But IL-6 inhibitors are too crude a therapy https://t.co/NT9rmu4
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
These treatments looks so promising in animals models, in phase 1, 2 & even 3 trials. All to no avail. For some, like me, the dream lives on! One day the right modulatory agent will be found. But IL-6 inhibitors are too crude a therapy https://t.co/NT9
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: There is a lot of speculation on why Germany has such a low mortality. My theory: they practice less ‘kitchen sink medicine’…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @RyanMarino: “The administration of any unproven drug as a “last resort” wrongly assumes that benefit will be more likely than harm.” ht…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
Muy importante 👇 Ante la neurosis colectiva, no debemos perder el norte. Todos los tratamientos para el SARS-COV-2 tienen un nivel de evidencia pobre. Hay que ser cautos.
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
This article is mandatory reading for all fellow clinician. That means YOU #COVID4MDs #FOAMcovid
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: There is a lot of speculation on why Germany has such a low mortality. My theory: they practice less ‘kitchen sink medicine’…
There is a lot of speculation on why Germany has such a low mortality. My theory: they practice less ‘kitchen sink medicine’ #COVID19 #covid4MDs
Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @ToshiAkima: @DavidJuurlink Hard to know whether to laugh or cry. They didn't do this during the Ebola epidemic where the same orphan dr…
@medicalaxioms @allen_phd Are we really citing a 102 y/o article to justify this? Note that it was tried during the Ebola epidemic but found to be wanting. In fact all the same mistakes made in the Ebola epidemic are being repeated in the hope that "this t
RT @ToshiAkima: @DavidJuurlink Hard to know whether to laugh or cry. They didn't do this during the Ebola epidemic where the same orphan dr…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @LaurentLantieri: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Ph…
RT @LaurentLantieri: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Ph…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
Dans l'Ébola, plusieurs traitements ont été tentés de façon anecdotique mais aucun de ces traitements n’a prouvé son utilité. Voilà que l'histoire se répète avec la COVID-19. Cet article explique pourquoi il ne faut pas répéter ces mêmes erreurs. #COVID19
RT @hewlett_angela: Important statement in @JAMA_current on the use of investigational therapeutic agents for #COVIDー19 from Dr. Andre Kali…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
Kalil paper posted here. See discussion of failure to define best approaches to Ebola #COVID19 https://t.co/dGJRYjoH3B
RT @RyanMarino: “The administration of any unproven drug as a “last resort” wrongly assumes that benefit will be more likely than harm.”
RT @RyanMarino: “The administration of any unproven drug as a “last resort” wrongly assumes that benefit will be more likely than harm.”
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
@DavidJuurlink Hard to know whether to laugh or cry. They didn't do this during the Ebola epidemic where the same orphan drugs were tested and failed to be wanting #COVID4MDs #FOAMcovid https://t.co/NT9rmu4scV
Why were new therapies not discovered during #ebola outbreak? One reason is because virtually all studies were single-group interventions without controls. If we learn nothing, there will be no proven treatments for future #coronavirus pandemics. #RCT #cli
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @CochraneJapan: JAMAよりCOVID19での適応外使用に対する警鐘です。 エボラ感染が拡がった際に適応外使用が色々行われましたが、最終的に効果や安全性が証明されたものはありませんでした。 適応外使用があると、患者が死亡した理由が病気か薬かわかりません。生…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @LaurentLantieri: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Ph…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
@Over400ppm @pharmaconnect @DougDeibele and people with corona virus infections are more likely to have heart issues so the combination has the potential to be deadly https://t.co/QIWRwZJqfU
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @CochraneJapan: JAMAよりCOVID19での適応外使用に対する警鐘です。 エボラ感染が拡がった際に適応外使用が色々行われましたが、最終的に効果や安全性が証明されたものはありませんでした。 適応外使用があると、患者が死亡した理由が病気か薬かわかりません。生…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network https://t.co/VZ9NOc9miS
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @lucasmorin_eolc: @RyanMarino "A common interpretation of off-label use and compassionate use of drugs is that if the patients died, the…
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
RT @gorskon: This is an incredibly important thing that even most doctors do not understand.
"A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true." https://t.co/L49vccDvMN