RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
🗣🗣🗣🗣
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
RT @JAMA_current: When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19,…
When a drug with unknown clinical effects is given to patients who have severe illness from a new disease like COVID-19, there is no way to know whether they benefited or were harmed if they were not compared to a concurrent control group. https://t.co/7F5
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/w5LM1t6kEF
RT @QUAMED1: #COVIDー19: In addition to the risk of harming patients without the possibility to detect the magnitude of #harm, #off-label dr…
#COVIDー19: In addition to the risk of harming patients without the possibility to detect the magnitude of #harm, #off-label drug use, #compassionate use and uncontrolled studies could discourage participation in #clinicaltrials, hampering knowledge gain ht
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/IXhfuAGQzy
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/pLcR5twFFM
RT @avkwong: My personal field that it has become like the wild west of treatment and everything is being used and tried #COVID19 #COVIDmar…
RT @FOAMecmo: Editorials & updates on #COVID19 @JAMA_current https://t.co/0oEVqXJ8fh https://t.co/kXIXS58N6E https://t.co/RWnVlaplSu review…
RT @avkwong: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics #COVID19 #COVIDmarath…
Aynen görüşüm budur. Placebo ile karşılaştırın bakalım tapındığınız ilaçları. Sonuçları görelim
RT @PreetiNMalani: Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/eeWbJiLVXm
RT @avkwong: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics #COVID19 #COVIDmarath…
RT @avkwong: My personal field that it has become like the wild west of treatment and everything is being used and tried #COVID19 #COVIDmar…
RT @JAMA_current: Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
"A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true." https://t.co/9yJNkYVyVJ
RT @FOAMecmo: Editorials & updates on #COVID19 @JAMA_current https://t.co/0oEVqXJ8fh https://t.co/kXIXS58N6E https://t.co/RWnVlaplSu review…
RT @FOAMecmo: Editorials & updates on #COVID19 @JAMA_current https://t.co/0oEVqXJ8fh https://t.co/kXIXS58N6E https://t.co/RWnVlaplSu review…
RT @FOAMecmo: Editorials & updates on #COVID19 @JAMA_current https://t.co/0oEVqXJ8fh https://t.co/kXIXS58N6E https://t.co/RWnVlaplSu review…
Editorials & updates on #COVID19 @JAMA_current https://t.co/0oEVqXJ8fh https://t.co/kXIXS58N6E https://t.co/RWnVlaplSu review https://t.co/gHQO4T6hNo hydroxychloroquine/azithro https://t.co/tR3OTA1KhI plasma https://t.co/Y0McwDnX73 @PreetiNMalani @ESIC
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network https://t.co/S5xieXLhJs
RT @JAMA_current: Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
RT @avkwong: My personal field that it has become like the wild west of treatment and everything is being used and tried #COVID19 #COVIDmar…
RT @JAMA_current: Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
RT @JAMA_current: Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
RT @JAMA_current: Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
Dr. Kalil's viewpoint at https://t.co/f52amB6MPt #escimtv #covidhalfmarathon #JAMALive ht @PreetiNMalani
My personal field that it has become like the wild west of treatment and everything is being used and tried #COVID19 #COVIDmarathon
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics #COVID19 #COVIDmarathon @JAMA_current https://t.co/pt3BfsDkUM
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/eeWbJiLVXm
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @Duke_ASET: Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/qrHILYmVGN
To frame this part of the discussion, we referenced this excellent @JAMA_current editorial from Kalil et al. https://t.co/US6mvJdZaT 10/14
RT @ABsteward: "The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments fo…
RT @ABsteward: "The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments fo…
RT @ABsteward: "The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments fo…
しかし、臨床効果が未知の薬剤が(#COVID19 など)新疾患で重症な患者に投与されたとき、並行した対照群と比較しなかった場合は、患者が有益性を享受したか、有害性を被ったか、を知る方法は無い。 https://t.co/P2a5kFqnpv
それでも、in vitro(#試験管内 での #培養実験)で SARS-CoV-2(#新型コロナウイルス)に対し活性を示した新旧の薬物が患者に投与された #症例報告 はあるが、比較対照群は無い。 https://t.co/P2a5kFqnpv
他の #感染症 のために in vitro(#試験管内 での #培養実験)で非常に有望である多数の薬物が #臨床研究 で失敗した。in vitro 活性が自動的に臨床的活性に変換されれば、あらゆる種類の #感染症 に対してより多くの #抗生物質 が利用可能になるであろう。 https://t.co/P2a5kFqnpv
多数の薬物は、異なる #コロナウイルス に対して in vitro(#培養実験)で活性を示すが、SARS-CoV-2(#新型コロナウイルス)など、ヒトにおけるあらゆる #コロナウイルス に対する薬物の有効性と安全性を裏付けた臨床的証拠は未だ無い。 https://t.co/P2a5kFqnpv
COVID-19の治療 — 大流行における適応外使用・未承認薬の人道的使用・ランダム化臨床試験 2020/3/24 #AndreKalil @unmc @NebraskaMed [https://t.co/T84rFuwaxJ] https://t.co/P2a5kFqnpv
RT @ABsteward: ⭐⭐In contrast, compared with RCTs, the administration of old or new drugs (eg,off-label use, compassionate use,single-group…
⭐⭐In contrast, compared with RCTs, the administration of old or new drugs (eg,off-label use, compassionate use,single-group cohorts, case-historical controls, clinical trials without controls) may be less safe, and moreover, will not lead to the discovery
RT @SteveJoffe: @mypathologistmd Three helpful papers: 1) https://t.co/BlkJ1h1SYb
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/TcJltPLhjP
"...the goal was to determine which was efficacious against Ebola. ... Why were new therapies not discovered? One reason is because virtually all studies were single-group interventions without concurrent controls..." https://t.co/nmyNrMhNjl
Cleaning out my inbox / open tabs today... found this article I meant to read awhile back. It's a good one. Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/Hl2HaesBCK
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @amandaasubiar: Excelente. Es de lo mejor que he leído. 👇
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @amandaasubiar: Excelente. Es de lo mejor que he leído. 👇
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @amandaasubiar: Excelente. Es de lo mejor que he leído. 👇
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @amandaasubiar: Excelente. Es de lo mejor que he leído. 👇 https://t.co/uCrOVY4Isr
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @amandaasubiar: Excelente. Es de lo mejor que he leído. 👇
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
Excelente. Es de lo mejor que he leído. 👇
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
RT @DanielRodMD: @atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. .…
@atipak @DanielSimancasR @DamarisIntriago @paomorejon @MaiadelC @rhidalgott @amandaasubiar Claro...si el paciente muere. ..es por la enfermedad, pero si sobrevive es por la medicación! Si X sucede posterior a Y; entonces X es consecuencia de Y. Esto se co
“ A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true.” https://t.co/QIPnukNQ0B
RT @ToshiAkima: These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the d…
RT @ToshiAkima: These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the d…
RT @ToshiAkima: @IsobelRonai @GaetanBurgio @NIH As long as it is in the context of a properly supervised and well-designed RCT, I have no p…
@IsobelRonai @GaetanBurgio @NIH As long as it is in the context of a properly supervised and well-designed RCT, I have no problems with it (but remain a sceptic) https://t.co/NT9rmu4scV
@GaetanBurgio @fred_rit There has never been a successful trial of immunosuppression for sepsis. They almost invariably increase mortality. Nature has put those cytokines there for a reason (to fight fires) and so you have to be wary of knocking them out b
RT @MSharifpourMD: This is a brilliant piece that was recently published in @JAMA_current about Off-Label and Compassionate drug use. I rec…
@connors_md As Chuck Esmon states at the start of this old talk "coagulation is, in fact, part of the innate immune response". But I suspect knocking out the immune response is mistaking the fire-engine for the firestorm [see JAMA quote https://t.co/NT9rmu
@andhen25 @PaulSaxMD Excellent metaphor. I agree we are mistaking the fire engine for the firestorm. Like TNFa inhibitors and steroids it's more likely to increase mortality. https://t.co/NT9rmu4scV Quote from JAMA article https://t.co/Pi1JN6OpuK https://t
@duality_man @realjurgmeister And he's a board certified family practitioner, is he? By the ABFM? What a convenience he's going against the FDA for prescribing hydroxychloroquine off label. https://t.co/hBv5GHLHyV You people are just not smart. https:/
Important and very readable. https://t.co/Sq9oRWsqBN
RT @MSharifpourMD: This is a brilliant piece that was recently published in @JAMA_current about Off-Label and Compassionate drug use. I rec…
RT @MSharifpourMD: This is a brilliant piece that was recently published in @JAMA_current about Off-Label and Compassionate drug use. I rec…
RT @lorakolodny: On the moral imperative of not just winging it... Or why randomized controlled trials must be done even amid this pandemic.
RT @MSharifpourMD: This is a brilliant piece that was recently published in @JAMA_current about Off-Label and Compassionate drug use. I rec…
RT @lorakolodny: On the moral imperative of not just winging it... Or why randomized controlled trials must be done even amid this pandemic.
RT @lorakolodny: On the moral imperative of not just winging it... Or why randomized controlled trials must be done even amid this pandemic.
@ahier The article states that "very surprisingly, the monoclonal antibodies that were trialled in eastern DRC did work" but I cannot find any evidence to support this claim https://t.co/oWihLHLrhf Other articles contradict it too https://t.co/NT9rmu4scV
@RetractionWatch @ivanoransky @CBCTheNational @CaulfieldTim The news that Remdesivir gave promising results when treating Ebola is news to me. Is there good evidence for this? https://t.co/NT9rmu4scV
@adyamisra @EpiEllie Other than in the US where potentially harmful Rx is declared a game-changer in the absence of proof, in the UK and Japan such trials are already planned, approved and underway https://t.co/NT9rmu4scV
@CNEWS Les nombreux lecteurs anglophones de #cnews pourront se referer à ce très bon article qui explique les pièges des traitements "compassionnels" hors études...https://t.co/38NwMnbEV7 https://t.co/6j4yAe9f6h
RT @smirioglu: Should not be forgotten, especially in times like these. Controlled studies are needed. #COVIDー19 https://t.co/pg5SGaOGQm ht…