新型コロナウイルス、治療薬の話はいろいろ出てるけど、こういうことがあるから、序盤で一点賭けはしないほうが良いと思う。
RT @dora_ph: @ph_lelouch ご査収ください。https://t.co/f7dge5AVL6
@DanielN61841575 @nderi_j @MattOduor @vincentochola @cnngaruiya @rmbatia @__anthonyng @TheOneHanded @SuaveNilote @KetanVora4 @rmajab @AP "A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died
RT @dora_ph: @ph_lelouch ご査収ください。https://t.co/f7dge5AVL6
@ph_lelouch ご査収ください。https://t.co/f7dge5AVL6
@vm_roma @eduardoroberty A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true. https
Excerpt: In the 2014 Ebola outbreak, close to 30 000 individuals developed Ebola viral disease (EVD), and numerous therapies were tested against this virus,
"A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true". https://t.co/HUTctzMkxH
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/VPINQZymg1
Traitement du Covid19 hors AMM
Les essais cliniques randomisés sont la meilleure chance de trouver un traitement. Ils sont aussi la manière la plus éthique de traiter les patients, car nous ne pouvons pas savoir sans groupe contrôle si la guérison ou le décès sont dû à la maladie ou au
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
Good read about why we need RCTs in a pandemic (for HCQ, lopinavir/ritonavir, etc.) https://t.co/nZJRuqn88I
RT @SIDPharm: Check out the latest viewpoint published today in @JAMA_current "Treating COVID-19—Off-Label Drug Use, Compassionate Use, and…
Ou pourquoi recevoir un traitement non validé peut être délétère pour plein de monde. https://t.co/nUr2lWYjeN
Vous pouvez aussi lire ceci, c’est extrêmement intéressant ⤵️ https://t.co/dvUQD6yOSe
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
RT @tal7291: Kalil AC. Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics. JAMA. Publ…
RT @tal7291: Kalil AC. Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics. JAMA. Publ…
Kalil AC. Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics. JAMA. Published online March 24, 2020. doi:10.1001/jama.2020.4742 https://t.co/gOVNPXYZsQ Just because you can, doesn't mean you should.
RT @GhanaboyPharmd: This is really good!! Thanks @JeffreyFudin for recommending this article.. Sums up everything i have been wrestling wit…
RT @SIDPharm: Check out the latest viewpoint published today in @JAMA_current "Treating COVID-19—Off-Label Drug Use, Compassionate Use, and…
@morethanmySLE @RollingStone Clinical trials have a reason “hydroxychloroquine...have a variety of adverse effects, including increasing the risk of cardiac death. The administration of any unproven drug as a “last resort” wrongly assumes benefit“ https://
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
https://t.co/1myUXTcxHc Duas diferentes fontes deixando claro que está cedo apostar todas as fichas na cloroquina. Me estranhou hoje a colocação do Dr. David Uip
@realDonaldTrump I am sure you won't understand this, but you should attempt to read it anyway so you might stop saying stupid stuff. https://t.co/AaK2V5af9i
"A common interpretation of off-label use and compassionate use of drugs (such as hydroxychloroquine) is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true." https://
RT @__mikala__: @FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin su…
@FZores D'ailleurs dans le même sens un point de vue intéressant sur Jama(https://t.co/3vFLbvNKhZ )qui va même plus loin sur l'usage compassionnel...
RT @AndersPerner: Randomized care better than random care for both patients and societies Treating COVID-19—Off-Label and Compassionate Us…
@Yamiche Actually. It does. paragraphs 4, 5, 6 " hydroxychloroquine, azithromycin, and lopinavir-ritonavir have a variety of adverse effects, including QT prolongation, torsades de pointes, hepatitis, acute pancreatitis, neutropenia, and anaphylaxis."http
RT @TClarityLane: @mcleanky85 @politiwars @tedlieu Please pay attention to paragraphs 4, 5, 6 " hydroxychloroquine, azithromycin, and lopi…
RT @RenaGosser: Reminder: “A common interpretation of off-label use and compassionate use of drugs is that if the patient died, they died f…
Reminder: “A common interpretation of off-label use and compassionate use of drugs is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true.” https://t.co/eMIY6FRwZp
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
Sem ensaios clínicos vos randomizados, não há como concluir sovre a efetividade de um tratamento para uma doença. // Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/AEmao9hdIv via @JAMA_current
RT @Saludteca: #AyudaBiblioteca Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics ht…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
RT @Saludteca: #AyudaBiblioteca Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics ht…
RT @Saludteca: #AyudaBiblioteca Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics ht…
#AyudaBiblioteca Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics https://t.co/kk6bQb0ydx https://t.co/7rYptYzDJn
@Dereklowe @dandrezner Just keep trying to push the science of why we need good clinical trial data to keep us safe. #MakeScienceMatterAgain https://t.co/80Pr0lXiN3
@johnlegend I hope people will take a moment to read the actual science behind we don't just jump on trump's snake oil salesman bandwagon...there is a reason we have clinical trials https://t.co/80Pr0lXiN3
For the next uneducated person not paying attention to the physicians and scientists: "hydroxychloroquine, ....azithromycin,''' have a variety of adverse effects, including QT prolongation...hepatitis, acute pancreatitis, neutropenia, and anaphylaxis. http
@RedRaiderArms @mcleanky85 @politiwars @tedlieu Science: As a practical example, chloroquine/hydroxychloroquine, azithromycin, and lopinavir-ritonavir have a variety of adverse effects, including QT prolongation, torsades de pointes, hepatitis, acute panc
@mcleanky85 @politiwars @tedlieu Please pay attention to paragraphs 4, 5, 6 " hydroxychloroquine, azithromycin, and lopinavir-ritonavir have a variety of adverse effects, including QT prolongation, torsades de pointes, hepatitis, acute pancreatitis, neutr
RT @ToshiAkima: @GaetanBurgio Hydroxychloroquine plus Azithromycin is a highly cardiotoxic drug combination. HCQ was previously tried out o…
@GaetanBurgio Hydroxychloroquine plus Azithromycin is a highly cardiotoxic drug combination. HCQ was previously tried out of desperation for Ebola using a panic-driven kitchen sink methodology and found wanting. First: DO NOT HARM https://t.co/NT9rmu4scV
RT @rvcohen: Usar remédios off label por crença e otimismo As vezes NÃO É A MELHOR OPÇÃO. Todos querem tratamentos eficazes e seguros. Mas…
RT @DraJuPereira: Isto não é verdade. Tem fundamento científico sim e resultados suficientes para usar neste momento que muitos estão morre…
@fernandoulrich Leia esse tambem https://t.co/6hOvAFTZLU
Despite it's hard, "Drugs should not be given just for compassion without good scientific evidence that they work, because they can do more harm than good." Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.c
@hbredda Vale a leitura https://t.co/m79lnTsZQU
@fernandoulrich Leiam por favor. https://t.co/m79lnTsZQU
RT @sjwill99: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy…
RT @quocdngu: Des raisons pour lesquelles l'hydroxychloroquine et autres Rx en "mesures d'exception et d'espoir" est probablement une mauva…
@beastieboyz1976 @ieVincentDemers @Vadeboncoeur_Al @raoult_didier Merci pour la bonne discussion. Je comprends votre idée, elle est bonne. Mais ce qui est différent de votre exemple c'est que le médicament en question est en pénurie. Voici d'autres bons ar
Isto não é verdade. Tem fundamento científico sim e resultados suficientes para usar neste momento que muitos estão morrendo...
RT @rvcohen: Usar remédios off label por crença e otimismo As vezes NÃO É A MELHOR OPÇÃO. Todos querem tratamentos eficazes e seguros. Mas…
RT @sjwill99: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy…
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/cjU5apEpK7
@fernandoulrich Ciência que demonstra segurança e eficácia de um tratamento não ė torcida. Economista manco que defende com paixão remédios ,virologista oportunista não dão sustentação para qquer tratamento. Seriedade é fundamental. https://t.co/m79lnTsZQ
Chega de pseudo economistas,pseudo virologistas e contadores de história. https://t.co/m79lnTsZQU
Usar remédios off label por crença e otimismo As vezes NÃO É A MELHOR OPÇÃO. Todos querem tratamentos eficazes e seguros. Mas paixão não combina com ciência segura. Apareceram virologistas e espertalhões de todo canto. https://t.co/m79lnTsZQU
Wise comment. Please let’s avoid non rational and non scientific passionate measures https://t.co/m79lnTsZQU
RT @ymori117: JAMA論説「パンデミックにおけるCOVID-19への薬物適応外使用、未承認薬アクセス制度による使用、無作為比較試験」 https://t.co/u0soye2bWO 「適応外・未承認薬の一般的な解釈は、患者が死亡したら病気の所為だが、生存したら薬物…
Terrific viewpoint! Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/8MHsW3Nwxs
JAMA論説「パンデミックにおけるCOVID-19への薬物適応外使用、未承認薬アクセス制度による使用、無作為比較試験」 https://t.co/u0soye2bWO 「適応外・未承認薬の一般的な解釈は、患者が死亡したら病気の所為だが、生存したら薬物のお陰というものだが、それは違う。」
@Medscape Nonsense. It has been tried and failed before. The kitchen sink approach is more likely to violate the rule of DO NO HARM. The only reason you tweet such nonsense out is because you want to kill more people for the glory of your beloved Trump htt
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @CochraneJapan: JAMAよりCOVID19での適応外使用に対する警鐘です。 エボラ感染が拡がった際に適応外使用が色々行われましたが、最終的に効果や安全性が証明されたものはありませんでした。 適応外使用があると、患者が死亡した理由が病気か薬かわかりません。生…
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
@mscondetoledo Dar una droga no probada como "último recurso" asume por error que beneficio supera daño. No se puede saber si los pacientes se han beneficiado o no si no se comparan con un grupo control: si el paciente muere es la enfermedad, si sobrevive
@PaulMaxit RCT could help – Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics https://t.co/P14NKf4vzW #Covid19
#Cholorquine #essaiDiscovery Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics https://t.co/P14NKf4vzW
RT @joaqmorera: Que cuando se dice que hay que realizar tratamientos basado en ensayos clínicos es por algo Treating COVID-19—Off-Label and…
Es la verdad, buen artículo, pero también es verdad que con muchos pacientes no se podía esperar a los ensayos, había que probar lo que se pudiera...en base a la experiencia previa con SARS y MERS
RT @jvillacastin: Tenemos mucho que aprender y mejorar. Realizar estudios con grupo control para probar fármacos, es fundamental para trata…
RT @joaqmorera: Que cuando se dice que hay que realizar tratamientos basado en ensayos clínicos es por algo Treating COVID-19—Off-Label and…
RT @jvillacastin: Tenemos mucho que aprender y mejorar. Realizar estudios con grupo control para probar fármacos, es fundamental para trata…
"Common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true" https://t.co/jPE82CA4Je
RT @joaqmorera: Que cuando se dice que hay que realizar tratamientos basado en ensayos clínicos es por algo Treating COVID-19—Off-Label and…
Que cuando se dice que hay que realizar tratamientos basado en ensayos clínicos es por algo Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/rTLWvKnBDD