RT @joaqmorera: @SR_LopezAlonso @Nopanaden @mariagg26 @TheLancet Aquí una valoración sensata referente a la necesidad de ensayos clínicos q…
@SR_LopezAlonso @Nopanaden @mariagg26 @TheLancet Aquí una valoración sensata referente a la necesidad de ensayos clínicos que avalen los tratamientos https://t.co/ObrULUAG9U
Tenemos mucho que aprender y mejorar. Realizar estudios con grupo control para probar fármacos, es fundamental para tratar situaciones #COVID2019.Si existiera una mínima organización,con los medios actuales podrían haberse hecho ya y tendríamos resultados
RT @ToshiAkima: These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the d…
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @ToshiAkima: These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the d…
RT @ToshiAkima: These treatments looked so promising in animals models, in phase 1, 2 & 3 trials. All to no avail. For some, like me, the d…
RT @CochraneJapan: JAMAよりCOVID19での適応外使用に対する警鐘です。 エボラ感染が拡がった際に適応外使用が色々行われましたが、最終的に効果や安全性が証明されたものはありませんでした。 適応外使用があると、患者が死亡した理由が病気か薬かわかりません。生…
RT @ToshiAkima: @ELassMD @GrimshawJeremy @ChooseWiselyCA Great list. I am already seeing point 9 about only using experiment treatments wit…
RT @ToshiAkima: @ELassMD @GrimshawJeremy @ChooseWiselyCA Great list. I am already seeing point 9 about only using experiment treatments wit…
A reminder of the danger of administering untested drugs, forgoing randomly controlled studies.
RT @sjwill99: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy…
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network https://t.co/SJZ2OyFpcm
Most of what works in a test tube doesn't work in real people. Guesswork and hope are at least as likely to harm as help. Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/EKHVbYE9Hq
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/eDwTInMTDa
Required reading for anyone treating COVID in my opinion: https://t.co/T19nnHkcAy
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics https://t.co/6ECWIvY7o7
@jsenior64 Totalmente deacuerdo. Aquí un editorial de JAMA que esboza muy bien la situación. https://t.co/rEAof8lI3E
RT @villesallinen: It is amazing that this is not clear to every doctor. The drugs used to treat #COVID19 should be given within a randomiz…
RT @villesallinen: It is amazing that this is not clear to every doctor. The drugs used to treat #COVID19 should be given within a randomiz…
@Paco_Glez_ @BelenPadi @RaquelBlascoR @drmiguelmarcos @AieSalud @lluisizquierdo @itato @m_entrenamiento @chuchencio @manyez @MiguelDlaCamara No solo es admisible, es necesario: no sabemos si los fármacos pueden no solo no estar haciendo nada, sino producie
It is amazing that this is not clear to every doctor. The drugs used to treat #COVID19 should be given within a randomized trial to really find out which one(s) help(s). @Ferchu_Ortiz #koronafi
highly recommended read “A common interpretation of off-label use and compassionate use of drugs is that is that if the patient died, they died from the disease, but if the patient survived, they survived because of the given drug. This is not true” https:
RT @ToshiAkima: @ajaysheshadri @MaxKonigMD Totally agreed as this JAMA article tweet out by Cochrane Japan outlines https://t.co/NT9rmu4scV
@ajaysheshadri @MaxKonigMD Totally agreed as this JAMA article tweet out by Cochrane Japan outlines https://t.co/NT9rmu4scV
RT @ToshiAkima: @medpedshosp @kidney_boy Yes, cannot possibly agree more. Please don't panic and visit cavalier uncontrolled experimentatio…
@medpedshosp @kidney_boy Yes, cannot possibly agree more. Please don't panic and visit cavalier uncontrolled experimentation upon your patients outside the supervision within a controlled trial. FIRST DO NO HARM! https://t.co/NT9rmu4scV
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
An important article highlighting how unproven drugs for Covid-19 like chloroquine, azithromycin, and lopinavir-ritonavir shouldn’t be administered as a last resort without knowing whether the potential benefits will outweigh the harm. https://t.co/Ur7UptS
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
RT @ToshiAkima: @whereisdaz @Kaubo Cochrane Japan tweeted this JAMA article out and I agree with them about never letting a good crisis go…
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
RT @CAmarelli74: The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments f…
The rapid and simultaneous combination of supportive care and RCTs is the only way to find effective and safe treatments for COVID-19 and any other future outbreak. Treating #COVID Off-Label Drug Use, Compassionate Use, and RCT During Pandemics JAMA https:
RT @Ferchu_Ortiz: Couldn’t agree more @ERAEDTA @ESOTtransplant @HUS_uutisoi
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
RT @nandoaimar: Muy importante 👇 Ante la neurosis colectiva, no debemos perder el norte. Todos los tratamientos para el SARS-COV-2 tienen u…
RT @Ferchu_Ortiz: Couldn’t agree more @ERAEDTA @ESOTtransplant @HUS_uutisoi
@MJA_Editor Cochrane Japan also drew this JAMA article to our attention. Most of the drugs being tried vs COVID-19 are orphans drugs that already failed vs Ebola. Random experimentation is being repeated in the hope that "this time it will be different" #C
RT @ToshiAkima: @whereisdaz @Kaubo Cochrane Japan tweeted this JAMA article out and I agree with them about never letting a good crisis go…
@whereisdaz @Kaubo Cochrane Japan tweeted this JAMA article out and I agree with them about never letting a good crisis go to waste. If we indulge in uncontrolled cavalier adventurism, as we did in the Ebola pandemic, we will learn nothing and patients WIL
RT @cobatoma: Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los paci…
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/E5BOeyZtiK
Dar una droga no probada como "último recurso" asume por error que el beneficio supera el daño. No se puede saber si los pacientes se han beneficiado o dañado si no se comparan con un grupo control: si el paciente muere es por la enfermedad, si sobrevive
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/MvusJfGEaw
@XLRbyXLR @pdousteblazy Parlez pour vous. Et puis documentez vous Voici un autre lien. https://t.co/GKADkWjMCZ
“The administration of any unproven drug as a ‘last resort’ wrongly assumes that benefit will be more likely than harm.” #COVID19 https://t.co/q6fog7VofJ
Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network https://t.co/XheRHuk5z1
This is so important, lessons from Ebola outbreak in 2014 "virtually all studies were single-group interventions without concurrent controls, which led to no definitive conclusion related to efficacy or safety" here we go again https://t.co/yflxmRMSS3
@feliciaTSR Cochrane Japan tweet this out. The argument is that drugs of unproven efficacy must only be used in the context of a RCT (sorry to say I am seeing this being violated). The Canadians also put this in their recommendations. See attached JAMA art
RT @DanyaRoshdy: THIS. 👏👏👏 Everyone taking care of patients with #COVID19 should read. https://t.co/kQz4f7ZdGC
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
@ELassMD @GrimshawJeremy @ChooseWiselyCA Great list. I am already seeing point 9 about only using experiment treatments within the context of a supervised RCT being violated despite my pleas for clinicians to read this JAMA article https://t.co/NT9rmu4scV
Article sur « l’éthique » du placebo en pandémie. Va à l’encontre des propos du Pr Raoult. https://t.co/lHmoFI6EiL
@morateur @vbenard https://t.co/Fi6nuQIBjP Bonne lecture cet article du JAMA sur ces considérations éthiques
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
RT @RichardJHankins: Great viewpoint in JAMA by Dr Andre Kalil on the need of RCTs in a pandemic. Agree that in off label use patient death…
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/9VdpLKazW0
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
RT @alhkim: (6) Compassionate use of #hydroxychloroquine for hospitalized #COVID19 patients should be reconsidered if the patients qualify…
Considerations for adaptive trials. Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/3Qg33vHVVh
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
RT @ChandyJohnLab: I heartily agree with this eloquent plea for RCTs and data-based treatment of #COVID18 by Andrew Kalil. I am truly disma…
RT @DrMCecconi: New drugs during this pandemic? First do not harm. If seeking benefit, do not assume no harm. We have the tools to do resea…
THIS. 👏👏👏 Everyone taking care of patients with #COVID19 should read. https://t.co/kQz4f7ZdGC
RT @Duke_ASET: Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/qrHILYmVGN
@ZE_wanker Dr. Raoult's reputation is... less than perfect. But more importantly we have repeatedly attempted to use chloroquine as an antiviral in the past and it has not worked: https://t.co/BO4ga4WlfL
Treating COVID-19—Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/qrHILYmVGN
RT @IDPharmacometrx: Excellent overview of the therapeutic misconception as it pertains to #COVID19
RT @MedecineLibre: «By participating in an RCT, both patients and clinicians can benefit from the unique opportunity to directly contribute…
@VelezNephHepato We are letting a good crisis go to waste...again, just as with the Ebola epidemic and the same orphan drugs are being trotted out all over again https://t.co/NT9rmu4scV #COVID4MDs
🔵 Article | Treating #COVID19-Off-Label and Compassionate Use and Clinical Trials During Pandemics https://t.co/MRupCq8EZM
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
(JAMA) Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics https://t.co/6uEDvtCqzi
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
RT @poyanmehr: Highly recommend this perspective in JAMA https://t.co/HUrDniA44p https://t.co/ADXnfKCwoU
PandemiaCOVID-19: El tratamiento se limita a ensayos clínicos, medicamentos de uso compasivo y medicamentos off label....@XavierSnchz @docmundele https://t.co/0fvUvT9lSP
RT @IDPharmacometrx: Excellent overview of the therapeutic misconception as it pertains to #COVID19
Estudio de nuevas drogas en COVID #medicina 19 https://t.co/RlJZFeuo7t
@Descartes_Ghost @FZores @FerryDanini @foretdesciences Si vous n'êtes pas irrémédiablement atteint du syndrôme de Dunning-Kruger, auquel cas toute discussion avec vous est définitivement vaine, prenez le temps de lire ceci. https://t.co/S0fVcmoBBs
RT @IDPharmacometrx: Excellent overview of the therapeutic misconception as it pertains to #COVID19