@maiti_86 それではいったいなぜ「LDL-Cは心血管疾患の原因」だとわかるのか?スタチンだけではなく「数多くのさまざまな種類の臨床研究および遺伝学研究から得られた一貫した証拠」[ https://t.co/NmcIxl5HKw ]によります。
@NzyenR @MiocanDanijel Yes there is Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel - PubM
@PeterPrybak87 @DoctorTro Ok so you don't understand anything about it at all. No surprise. This is the consensus statement of experts. https://t.co/CGsBjs9zN3 Notice, 'the disease effects all mammals, and has never failed to replicate'. That's where the
@maiti_86 提示した論文[ https://t.co/NmcIxl59UY ]にも機序について述べられています。Criteria for causalityのPlausibilityのあたり。Plausibilityは、妥当性とか説得性とか訳されています。
@maiti_86 さて、宿題になっていた「薬剤の使用なしでコレステロールの値が死亡率にどう影響するか、をRCTできますか?」ですが、答えは「できます」。すごいでしょ。文献はいろいろありますが、前回提示したFerence BA et al.[ https://t.co/NmcIxl5HKw ]でも言及されています。
@maiti_86 European Atherosclerosis Society Consensus Panelでは明確に"Low-density lipoproteins cause atherosclerotic cardiovascular disease."、つまりLDLコレステロールは心血管系疾患の原因だとしています[ https://t.co/NmcIxl5HKw ]。
@PierreKory @MidwesternDoc https://t.co/B4t0sdqjXp Oh really?
@CatPoopSandwich @PaulJRamirez @ThePrimal_Pod You're not grasping the preponderance of evidence. If we elevate the LDL of any mammal, it will develop CVD and diabetes. You need to explain what all mammals have in common, that humans don't, that this should
@bigfatsurprise @The_Wonder_Who The experiment doesn't fail in any mammal. Fat feeding causes diabetes and CVD in every species studied. https://t.co/9s1orSeMix LCHF doesn't reverse T2D, but it will mitigate symptoms, and that is confused as reversal whi
@jimmy_muthami @SergiEscanes Epidemiological studies, Mendelian Randomization studies, randomized controlled trials say different. https://t.co/YvHW6Gow9O Now you provide your evidence.
@jimmy_muthami @BHBEnjoyer @realFredddd @ketogrillbakery @realDaveFeldman Yes LDL is the cause of the disease. There are other factors influencing severity, but LDL alone causes the disease. https://t.co/D3wzAITzdW
@srtyi45685175 @BioLayne @drcateshanahan And if so back it up with trials please. I will give you my evidence to show it is causal. https://t.co/hX0A8zK3Xf
@JaafarBinSalah Yeah I see Bill as intuiting a bradford hill criteria, which the founders of mathphyz didn't adhere to so its not their tradition. What RSM needs is a society that publishes consensus statements. Here's a good example https://t.co/9s1orSees
@kmiladi2 @MrHollon @nutrition_facts @YouTube The diseased group ate 26-30% calories from lard with 2% cholesterol and the rest was chicken and fish. You're hyperfocused on a single experiment. As I mentioned, there is not a mammal we can't induce atherosc
@SkepticalCent @LDLSkeptic Last try then you go away. I think you are polluted by the BS charlatans. https://t.co/M9yJ2OThPF
@realtek12345 To nieprawda, że nie ma badań łączących wysoką wartość LDL z chorobami sercowo-naczyniowymi, jest ich mnóstwo. https://t.co/eGj5eACbBH https://t.co/ECoiWEP6dW
@jimmy_muthami @MohammedAlo I already did. You clearly didn’t read it https://t.co/HP6Ht96gBl
@jimmy_muthami @MohammedAlo Can you answer the 1st question? Many multivariable analyses adjusting for other confounding factors show ApoB/LDL increases athero. Genetic studies show the same. https://t.co/HP6Ht95ILN How do you explain halting of athero
RT @GladstoneB81859: @ifixhearts I no longer accept the paradigm that the Earth is round. https://t.co/DxHKFnExnS https://t.co/bu3RqSMZwB
Great response! Little kids run his account and keep posting the same nonsense over and over again! Another version of that chart of over 20 million person years of follow up that looked at ever study on LDL-C without cherry picking. https://t.co/kjLSJQu19
@ifixhearts I no longer accept the paradigm that the Earth is round. https://t.co/DxHKFnExnS https://t.co/bu3RqSMZwB
@deportriggers @AlpacaAurelius 2/ [Borén] is the second of a pair of companion documents sponsored and published by the European Atherosclerosis Society. The first is [Ference 2017]. https://t.co/MulfoIJSXW
@jaker1419 @KenDBerryMD You can’t be this dumb. You are welcome DA https://t.co/M9yJ2OThPF
@e_augusto31 @Babygravy9 Finally, LDL (all types) has proven causal relation with cardiovascular disease, see the European Atherosclerosis Society Consensus Panel. Based on RCT, mendelian randomization studies and prospective cohorts using Hill causality c
@pablofariasn @nntaleb https://t.co/xp9xffrCot You can find the individual studies in this good overview article.
@RasmussenT56381 @MichelleZeh1968 @SeloSlav Please don’t insult me. Ask people with FH if cholesterol plays no part in CVD. Or I can show you over 20 million patient years of data to prove that LDL plays a significant role. There you go. Enjoy your steak t
@RasmussenT56381 @LetFrdmRing1776 Only 20 million data points proving LDL is causal. But go ahead and self medicate yourself. Just ask your twitter followers to help you when you have your MI 🤣👍they may even be able to do your PCI for you online. Like a do
@muggebugg @triagemethod @matt_mingkee @nicknorwitz This paper - animal, epidemiological , genetic, RCTs etc studies with > 20 million person years concludes: "Consistent evidence from numerous and multiple different types of clinical and genetic studie
@tommyspianocor1 @triagemethod Flat earth level idiocy https://t.co/HP6Ht96gBl
@jasongordo626 @ItsCourtneyLuna Did you even check the Affiliations on the paper you didn't even link but stole that chart from? I wonder why lipid disorders clinics would want to fund that study? Sure seems like it would increase their profits... https
@tommyspianocor1 @SamaHoole There are over 20m data points to prove LDL is causal of ASCVD. Go away you moron and go and watch ghostbusters or the twighlight zone. https://t.co/hX0A8zKBMN
@NorCalRoe78 @dranthonygustin @AlpacaAurelius No the evidence is not mixed. You just don't understand it. See the consensus statement, all scientific disciplines agree that dietary saturated fat of animal origin causes disease. There is no other possible c
@RustySashwaite @MasalaFry69 @MichaelMindrum Yes. The paper above and the one before it are what I would use: https://t.co/TVS09etegb
@MasalaFry69 @TrainingInNYC @KenDBerryMD However, as the concentration of LDL-C increases above this level, the probability of intimal retention of LDL leading to the initiation and progressive development of atherosclerotic plaque increases in a dose-depe
@ThelastStyleb16 @drpablocorral @society_eas False. https://t.co/M9yJ2OTPFd causal dummy. Catch up
@tommyspianocor1 @DrNadolsky False. https://t.co/M9yJ2OTPFd. There are zero top cardiologists who don’t believe apob is not the main driver of ASCVD. Zero
@AbrahamAubry Stabilize what is already present and hopefully prevent further progression. Here is a great consensus paper from the European Atherosclerosis Society panel if you want to have some literature available https://t.co/vbzee4xyj0
RT @MohammedAlo: @dr_cois @drscottyk @TheNutrivore Pathophysiology of Coronary Artery Disease Good place to start if you want an introducti…
RT @MohammedAlo: @dr_cois @drscottyk @TheNutrivore Pathophysiology of Coronary Artery Disease Good place to start if you want an introducti…
@dr_cois @drscottyk @TheNutrivore Pathophysiology of Coronary Artery Disease Good place to start if you want an introduction to coronary artery disease. https://t.co/RaosmnJs9o Cholesterol, LDL, CVD, and ASCVD LDL causes ASCVD Ference and Boren EAS: Fe
@hormonedietdoc Lowering LDL-c does lower CVD though. https://t.co/DxHKFnExnS https://t.co/cW4ULioyQz
RT @realDaveFeldman: Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determin…
RT @realDaveFeldman: Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determin…
RT @realDaveFeldman: Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determin…
"Cumulative LDL arterial burden is a central determinant for the initiation and progression of atherosclerotic cardiovascular disease." Yes LDL is necessary but is it sufficient by itself. why does LDL get there to cause the atherosclrosis. I.e what
RT @realDaveFeldman: Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determin…
@realFredddd @realDaveFeldman @drpablocorral @theproof @Drpaulthornburg @nicknorwitz @Lipoprotein I would consider central driver and central determinant synonymous but I’m more than willing to be convinced otherwise - elaborate if you are willing Fred. 🙏🏻
RT @realDaveFeldman: Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determin…
Look to the 2017 EAS consensus itself –https://t.co/sEVEwxYVKd "Cumulative LDL arterial burden is a central determinant for the initiation and progression of atherosclerotic cardiovascular disease." https://t.co/876C8gE4dH
@raphaels7 @realDaveFeldman @theproof You seem to love to deny reality https://t.co/HP6Ht96gBl
@OhMelodylane @Marion436842126 @FightOn4ever55 @OhMelodylane you need your get out and get yourself some d1ck. I’m guessing 20m years of patient follow ups isn’t enough for you to prove the cholesterol hypothesis. https://t.co/hX0A8zK3Xf
@KarlbergErik @JacobGudiol @Klartsomspad @Perrre Så du väljer data från 40 mumier (selektiv grupp) med begränsad data framför t.ex. detta?: https://t.co/wHivGImG0e
@stathi_ @drpablocorral There are zero random control human trials that indicate high apob is protective from ASCVD. Zero. https://t.co/M9yJ2OThPF causative
@piaost @CaryKelly11 @Johnmcinnesliv1 Let me help dummy. SF drives apob apob drives CVD. CVD takes your tribe out quickly. A shame but oh well Darwin you know 🤷🏻♂️ https://t.co/M9yJ2OThPF causative
@arteesun @MohammedAlo Read this if you want to see actual high quality evidence. If this isn’t convincing there’s practically nothing you can be sure of in all of health science. https://t.co/EsKsVGtpRt
@arteesun @MohammedAlo If you want more than just extremely low quality unconvincing association data that is rife for confounders and terrible at establishing causation, here is an overview of multiple different independent lines of superior forms of evid
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @DrRumberger: So let me see if I get the analogy right: LDL is a surrogate like #cac is a surrogate to individual coronary plaque burden…
RT @DrRumberger: So let me see if I get the analogy right: LDL is a surrogate like #cac is a surrogate to individual coronary plaque burden…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @DrRumberger: So let me see if I get the analogy right: LDL is a surrogate like #cac is a surrogate to individual coronary plaque burden…
RT @DrRumberger: So let me see if I get the analogy right: LDL is a surrogate like #cac is a surrogate to individual coronary plaque burden…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
RT @Drlipid: A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFound…
A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFoundation @fhpatienteurope https://t.co/u4YoqebRIY https://t.co/fB8HTW4IkP
A simple updated graphic of mine on using the lab to evaluate LDL-mediated ASCVD risk. @nationallipid @society_eas @TheFHFoundation @fhpatienteurope https://t.co/u4YoqebRIY https://t.co/CXMr3vJS3N
@823jjd @FoodFirst_Ty https://t.co/M9yJ2OThPF causal son
@arteesun @CoachLamby @jimbovelure @degriffin10 @jimmy_muthami @SteakAndWeights This paper is written by a person whose career is built on denying LDL cholesterol. It's not very useful. Start with these instead: https://t.co/sZuZBzpnE0 https://t.co/NgNTL95
@_advg_ @SentientBlobBob https://t.co/M9yJ2OTPFd causative.
@hormonedietdoc https://t.co/M9yJ2OThPF. Causative. Catch up you 🤡
We have millions of patient-years of follow-up. SAFE. EFFECTIVE. LIFE-SAVING. PERIOD.
Were this actually true and “not debatable”, every health insurance in the country would offer a premium discount to those with low LDL-C and/or those on statin therapy. They do not because after analyzing the data, they determined that there would be no d
RT @MohammedAlo: @comebackking1 There is something called "criteria for causation" in statics. Brian Ference et al made sure they met all c…
@comebackking1 There is something called "criteria for causation" in statics. Brian Ference et al made sure they met all criteria for causation. Please read a basic statistic book. Here's 20 million data points. LDL-C causes ASCVD. It's not debatable. http