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Clinical Genetic Testing for Familial Hypercholesterolemia

Overview of attention for article published in Journal of the American College of Cardiology (JACC), August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
52 news outlets
blogs
1 blog
twitter
181 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
145 Dimensions

Readers on

mendeley
222 Mendeley
Title
Clinical Genetic Testing for Familial Hypercholesterolemia
Published in
Journal of the American College of Cardiology (JACC), August 2018
DOI 10.1016/j.jacc.2018.05.044
Pubmed ID
Authors

Amy C. Sturm, Joshua W. Knowles, Samuel S. Gidding, Zahid S. Ahmad, Catherine D. Ahmed, Christie M. Ballantyne, Seth J. Baum, Mafalda Bourbon, Alain Carrié, Marina Cuchel, Sarah D. de Ferranti, Joep C. Defesche, Tomas Freiberger, Ray E. Hershberger, G. Kees Hovingh, Lala Karayan, Johannes Jacob Pieter Kastelein, Iris Kindt, Stacey R. Lane, Sarah E. Leigh, MacRae F. Linton, Pedro Mata, William A. Neal, Børge G. Nordestgaard, Raul D. Santos, Mariko Harada-Shiba, Eric J. Sijbrands, Nathan O. Stitziel, Shizuya Yamashita, Katherine A. Wilemon, David H. Ledbetter, Daniel J. Rader

Abstract

Although awareness of familial hypercholesterolemia (FH) is increasing, this common, potentially fatal, treatable condition remains underdiagnosed. Despite FH being a genetic disorder, genetic testing is rarely used. The Familial Hypercholesterolemia Foundation convened an international expert panel to assess the utility of FH genetic testing. The rationale includes the following: 1) facilitation of definitive diagnosis; 2) pathogenic variants indicate higher cardiovascular risk, which indicates the potential need for more aggressive lipid lowering; 3) increase in initiation of and adherence to therapy; and 4) cascade testing of at-risk relatives. The Expert Consensus Panel recommends that FH genetic testing become the standard of care for patients with definite or probable FH, as well as for their at-risk relatives. Testing should include the genes encoding the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin 9 (PCSK9); other genes may also need to be considered for analysis based on patient phenotype. Expected outcomes include greater diagnoses, more effective cascade testing, initiation of therapies at earlier ages, and more accurate risk stratification.

Twitter Demographics

The data shown below were collected from the profiles of 181 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 222 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 29 13%
Researcher 25 11%
Student > Master 25 11%
Student > Ph. D. Student 20 9%
Student > Postgraduate 17 8%
Other 42 19%
Unknown 64 29%
Readers by discipline Count As %
Medicine and Dentistry 71 32%
Biochemistry, Genetics and Molecular Biology 38 17%
Agricultural and Biological Sciences 9 4%
Nursing and Health Professions 5 2%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 16 7%
Unknown 78 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 519. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2021.
All research outputs
#25,648
of 17,577,937 outputs
Outputs from Journal of the American College of Cardiology (JACC)
#63
of 13,780 outputs
Outputs of similar age
#817
of 285,201 outputs
Outputs of similar age from Journal of the American College of Cardiology (JACC)
#4
of 216 outputs
Altmetric has tracked 17,577,937 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,780 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,201 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 216 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.