1,230 followers
RT @ApprovedAmerica: Evidence-based medicine and big genomic data https://t.co/zToXEyggFT
3,763 followers
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
1,431 followers
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
1,796 followers
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
3,416 followers
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
477 followers
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
2,703 followers
Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly on evaluating the balance of health benefits & potential harms (#utility), as well as #implementation. <-- Ioannidis & @Mu
2,703 followers
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
260 followers
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
1,418 followers
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
2,295 followers
Indeed, all the more reason to ensure that (irreversible) risk reducing surgeries are not offered on the basis of such results. Is having surgery a behaviour to reduce risks??@MarteauTM
5,546 followers
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
8,959 followers
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
2,452 followers
To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour to reduce the risks https://t.co/wyFgwscL0S https://t.co/A4XshVYJsR https://t.co/jMyQisjIiF @MuinJKhoury @GrimshawJeremy @annekeluc
299 followers
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
266 followers
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
483 followers
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
179 followers
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
4,167 followers
Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) but also on evaluating health benefits and potential harms (clinical utility). Via @hmg_journal https://t.co/LJHi2QWIJ8 https://t.co/bXC
70,996 followers
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
2,372 followers
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
88 followers
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
14,285 followers
Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies. https://t.co/cDBcLUAEce https://t.co/ksp2TplJe7
136 followers
RT @DrKhouryCDC: Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/h…
5,697 followers
464 followers
9,438 followers
5,993 followers
RT @DrKhouryCDC: Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/h…
262 followers
14,285 followers
Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/hQyxqNEgYO https://t.co/sGMsjMVZRe
837 followers
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
3,801 followers
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
394 followers
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
14,285 followers
Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t.co/BcIQYzqfK3
20 followers
6) Article outlines 8 suggestions for designing Big Genomic Data research to be more evidence based. https://t.co/kOPouBJV6n (7/7)
20 followers
5) Big Genomic Data has a poor track record of actually altering health-related behavior for long periods of time https://t.co/kOPouBJV6n (6/7)
20 followers
4) To study Big Genomic Data in research, begin by designing studies to answer a specific clinical question, not just spitting in the wind, looking for something cool https://t.co/kOPouBJV6n (5/7)
20 followers
3) Data mining of genomic info is still not precise enough to identify a specific phenotype, so relay on EBM treatment with individual adjustment when appropriate based on Big Genomic Data https://t.co/kOPouBJV6n (4/7)
20 followers
2) Big Genomic Data studies are N-of-1, which are useful only for treatment of chronic, lifelong, well-understood diseases https://t.co/kOPouBJV6n (w/7)
20 followers
1) Genomic results must be interpreted in the context of the best available EBM data to determine an appropriate treatment for patients https://t.co/kOPouBJV6n (2/7)
20 followers
Ioannidis et al. discuss appropriate use of Big Genomic Data mining in the context of EBM. What are the best practices? https://t.co/kOPouBJV6n (1/7)
573 followers
RT @DrKhouryCDC: The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. htt…
80 followers
RT @DrKhouryCDC: The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. htt…
14,285 followers
The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. https://t.co/6zg74gOka4 https://t.co/Pip5DcOvrS
1,240 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
228 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
1,133 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
474 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
793 followers
#Evidence Based #Medicine and Big #Genomic #Data https://t.co/huFjFR6pWD #EBM #BigScience #BigData
374 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
1,332 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
3,961 followers
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
14,285 followers
Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies. #EBM #pm101. https://t.co/9fJBbhipRr https://t.co/4pLV6fR71U
221 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
195 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
12 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
3,527 followers
Of particular interest to @KatyJLBell and @BJWilson059: "#Evidence Based Medicine and #Big #Genomic #Data" by John Ioannides and @DrKhouryCDC https://t.co/2tkntLlbTH
5,648 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
287 followers
Evidence Based Medicine and Big Genomic Data | Human Molecular Genetics | Oxford Academic https://t.co/Bs8bHUogFz
2,425 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
1,796 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
8,039 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
1,532 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
1,201 followers
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
14,285 followers
Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9ZtXFo5i
1,690 followers
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
1,071 followers
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
1,288 followers
Interesting review on Evidence Based Medicine and Big Genomic Data https://t.co/Mk4cFmJNf1
2,775 followers
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
13,718 followers
Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is limited evidence of effect, is low quality and has a substantial risk of bias. At least the problem is in the open. https://t.co/a3gqI