RT @ApprovedAmerica: Evidence-based medicine and big genomic data https://t.co/zToXEyggFT
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
RT @SCSanderson: Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly…
Research on big #genomic data needs to focus not only on finding robust associations (#validity) but also more importantly on evaluating the balance of health benefits & potential harms (#utility), as well as #implementation. <-- Ioannidis & @Mu
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
Indeed, all the more reason to ensure that (irreversible) risk reducing surgeries are not offered on the basis of such results. Is having surgery a behaviour to reduce risks??@MarteauTM
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
RT @MarteauTM: To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour t…
To add – Evidence does not support high expectations that DNA-based or non-DNA-based predictions change people's behaviour to reduce the risks https://t.co/wyFgwscL0S https://t.co/A4XshVYJsR https://t.co/jMyQisjIiF @MuinJKhoury @GrimshawJeremy @annekeluc
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
RT @MuinJKhoury: Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) bu…
Research on genomics and big data needs to focus not only on finding robust predictive associations (clinical validity) but also on evaluating health benefits and potential harms (clinical utility). Via @hmg_journal https://t.co/LJHi2QWIJ8 https://t.co/bXC
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
RT @CDC_Genomics: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologie…
Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies. https://t.co/cDBcLUAEce https://t.co/ksp2TplJe7
RT @DrKhouryCDC: Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/h…
RT @DrKhouryCDC: Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/h…
Read CDC article to learn why randomized clinical trials are important to the success of genomic medicine. https://t.co/hQyxqNEgYO https://t.co/sGMsjMVZRe
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
RT @DrKhouryCDC: Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t…
Evidence-based medicine meets big genomic data. #bigdata #precisionmedicine. https://t.co/hQyxqNEgYO @venkmurthy https://t.co/BcIQYzqfK3
6) Article outlines 8 suggestions for designing Big Genomic Data research to be more evidence based. https://t.co/kOPouBJV6n (7/7)
5) Big Genomic Data has a poor track record of actually altering health-related behavior for long periods of time https://t.co/kOPouBJV6n (6/7)
4) To study Big Genomic Data in research, begin by designing studies to answer a specific clinical question, not just spitting in the wind, looking for something cool https://t.co/kOPouBJV6n (5/7)
3) Data mining of genomic info is still not precise enough to identify a specific phenotype, so relay on EBM treatment with individual adjustment when appropriate based on Big Genomic Data https://t.co/kOPouBJV6n (4/7)
2) Big Genomic Data studies are N-of-1, which are useful only for treatment of chronic, lifelong, well-understood diseases https://t.co/kOPouBJV6n (w/7)
1) Genomic results must be interpreted in the context of the best available EBM data to determine an appropriate treatment for patients https://t.co/kOPouBJV6n (2/7)
Ioannidis et al. discuss appropriate use of Big Genomic Data mining in the context of EBM. What are the best practices? https://t.co/kOPouBJV6n (1/7)
RT @DrKhouryCDC: The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. htt…
RT @DrKhouryCDC: The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. htt…
The non-evidence-based use of genomics and big data may be harmful and result in major waste of health care resources. https://t.co/6zg74gOka4 https://t.co/Pip5DcOvrS
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
#Evidence Based #Medicine and Big #Genomic #Data https://t.co/huFjFR6pWD #EBM #BigScience #BigData
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
RT @DrKhouryCDC: Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies…
Randomized controlled trials will continue to be the strongest arbitrator for the clinical utility of genomic technologies. #EBM #pm101. https://t.co/9fJBbhipRr https://t.co/4pLV6fR71U
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
Of particular interest to @KatyJLBell and @BJWilson059: "#Evidence Based Medicine and #Big #Genomic #Data" by John Ioannides and @DrKhouryCDC https://t.co/2tkntLlbTH
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
Evidence Based Medicine and Big Genomic Data | Human Molecular Genetics | Oxford Academic https://t.co/Bs8bHUogFz
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
RT @DrKhouryCDC: Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9Zt…
Read New CDC Paper: Evidence Based Medicine Meets Big Genomic Data. #EBM #pm101 https://t.co/6zg74gOka4 https://t.co/2g9ZtXFo5i
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
Interesting review on Evidence Based Medicine and Big Genomic Data https://t.co/Mk4cFmJNf1
RT @ProfMakris: Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is li…
Paper from Ioannidis suggesting that the value of Big Genomic Data in helping precision medicine is overstated. There is limited evidence of effect, is low quality and has a substantial risk of bias. At least the problem is in the open. https://t.co/a3gqI