Title |
Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China - Volume 24, Number 1—January 2018 - Emerging Infectious Diseases journal - CDC
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Published in |
Emerging Infectious Diseases, January 2018
|
DOI | 10.3201/eid2401.171297 |
Pubmed ID | |
Authors |
Vincent C.C. Cheng, Siddharth Sridhar, Shuk-Ching Wong, Sally C.Y. Wong, Jasper F.W. Chan, Cyril C.Y. Yip, Chi-Hung Chau, Timmy W.K. Au, Yu-Yan Hwang, Carol S.W. Yau, Janice Y.C. Lo, Cheuk-Kwong Lee, Kwok-Yung Yuen |
Abstract |
Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted. JEV RNA was detected in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid specimens. The second recipient had leukemia and received platelets after undergoing chemotherapy. This patient was asymptomatic; JEV infection was confirmed in this person by IgM seroconversion. This study illustrates that, consistent with other pathogenic flaviviruses, JEV can be transmitted via blood products. Targeted donor screening and pathogen reduction technologies could be used to prevent transfusion-transmitted JEV infection in highly JEV-endemic areas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 38% |
Georgia | 1 | 8% |
Venezuela, Bolivarian Republic of | 1 | 8% |
Brazil | 1 | 8% |
Unknown | 5 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 46% |
Scientists | 3 | 23% |
Practitioners (doctors, other healthcare professionals) | 3 | 23% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 19% |
Other | 4 | 9% |
Student > Ph. D. Student | 3 | 7% |
Student > Bachelor | 2 | 5% |
Researcher | 2 | 5% |
Other | 8 | 19% |
Unknown | 16 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 28% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Agricultural and Biological Sciences | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 5 | 12% |
Unknown | 15 | 35% |