| Title |
Diagnóstico y tratamiento de la hipercolesterolemia familiar en España: documento de consenso
|
|---|---|
| Published in |
Atención Primaria (ScienceDirect), April 2014
|
| DOI | 10.1016/j.aprim.2013.12.015 |
| Pubmed ID | |
| Authors |
Pedro Mata, Rodrigo Alonso, Antonio Ruiz, Jose R. Gonzalez-Juanatey, Lina Badimón, Jose L. Díaz-Díaz, María Teresa Muñoz, Ovidio Muñiz, Enrique Galve, Luis Irigoyen, Francisco Fuentes-Jiménez, Jaime Dalmau, Francisco Pérez-Jiménez, otros colaboradores |
| Abstract |
Familial hypercholesterolemia (FH) is a common genetic disorder, clinically manifested since birth, and associated with very high levels of plasma LDL-cholesterol (LDL-c), xanthomas, and premature coronary heart disease. Its early detection and treatment reduces coronary morbidity and mortality. Despite effective treatment being available, FH is under-diagnosed and under-treated. Identification of index cases and cascade screening using LDL-c levels and genetic testing are the most cost-effective strategies for detecting new cases and starting early treatment. Long-term treatment with statins has decreased the vascular risk to the levels of the general population. LDL-c targets are <130mg/dL for children and young adults, <100mg/dL for adults, and <70mg/dL for adults with known coronary heart disease or diabetes. Most patients do not to reach these goals, and combined treatments with ezetimibe or other drugs may be necessary. When the goals are not achieved with the maximum tolerated drug treatment, a reduction ≥50% in LDL-c levels can be acceptable. Lipoprotein apheresis can be useful in homozygous, and in treatment-resistant severe heterozygous, cases. This Consensus Paper gives recommendations on the diagnosis, screening, and treatment of FH in children and adults, and specific advice to specialists and general practitioners with the objective of improving the clinical management of these patients, in order to reduce the high burden of coronary heart disease. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 33% |
| Colombia | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 106 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 17% |
| Researcher | 18 | 16% |
| Student > Master | 13 | 12% |
| Student > Doctoral Student | 6 | 5% |
| Student > Postgraduate | 5 | 5% |
| Other | 17 | 15% |
| Unknown | 32 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 37% |
| Nursing and Health Professions | 9 | 8% |
| Agricultural and Biological Sciences | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Social Sciences | 3 | 3% |
| Other | 11 | 10% |
| Unknown | 35 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2023.
All research outputs
#7,722,459
of 25,394,764 outputs
Outputs from Atención Primaria (ScienceDirect)
#391
of 1,144 outputs
Outputs of similar age
#69,610
of 238,697 outputs
Outputs of similar age from Atención Primaria (ScienceDirect)
#15
of 33 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,144 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,697 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.