Title |
Population Genomics of Legionella longbeachae and Hidden Complexities of Infection Source Attribution - Volume 23, Number 5—May 2017 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, May 2017
|
DOI | 10.3201/eid2305.161165 |
Pubmed ID | |
Authors |
Rodrigo Bacigalupe, Diane Lindsay, Giles Edwards, J. Ross Fitzgerald |
Abstract |
Legionella longbeachae is the primary cause of legionellosis in Australasia and Southeast Asia and an emerging pathogen in Europe and the United States; however, our understanding of the population diversity of L. longbeachae from patient and environmental sources is limited. We analyzed the genomes of 64 L. longbeachae isolates, of which 29 were from a cluster of legionellosis cases linked to commercial growing media in Scotland in 2013 and 35 were non-outbreak-associated isolates from Scotland and other countries. We identified extensive genetic diversity across the L. longbeachae species, associated with intraspecies and interspecies gene flow, and a wide geographic distribution of closely related genotypes. Of note, we observed a highly diverse pool of L. longbeachae genotypes within compost samples that precluded the genetic establishment of an infection source. These data represent a view of the genomic diversity of L. longbeachae that will inform strategies for investigating future outbreaks. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 7 | 47% |
Turkey | 1 | 7% |
Benin | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 53% |
Scientists | 6 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 17% |
Researcher | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Student > Bachelor | 3 | 13% |
Professor > Associate Professor | 2 | 8% |
Other | 4 | 17% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 29% |
Agricultural and Biological Sciences | 3 | 13% |
Immunology and Microbiology | 3 | 13% |
Environmental Science | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Other | 3 | 13% |
Unknown | 4 | 17% |