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Presymptomatic ALS genetic counseling and testing

Overview of attention for article published in Neurology, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
6 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
34 Mendeley
Title
Presymptomatic ALS genetic counseling and testing
Published in
Neurology, May 2016
DOI 10.1212/wnl.0000000000002773
Pubmed ID
Authors

Michael Benatar, Christine Stanislaw, Eliana Reyes, Sumaira Hussain, Anne Cooley, Maria Catalina Fernandez, Danielle D. Dauphin, Sara-Claude Michon, Peter M. Andersen, Joanne Wuu

Abstract

Remarkable advances in our understanding of the genetic contributions to amyotrophic lateral sclerosis (ALS) have sparked discussion and debate about whether clinical genetic testing should routinely be offered to patients with ALS. A related, but distinct, question is whether presymptomatic genetic testing should be offered to family members who may be at risk for developing ALS. Existing guidelines for presymptomatic counseling and testing are mostly based on small number of individuals, clinical judgment, and experience from other neurodegenerative disorders. Over the course of the last 8 years, we have provided testing and 317 genetic counseling sessions (including predecision, pretest, posttest, and ad hoc counseling) to 161 first-degree family members participating in the Pre-Symptomatic Familial ALS Study (Pre-fALS), as well as testing and 75 posttest counseling sessions to 63 individuals with familial ALS. Based on this experience, and the real-world challenges we have had to overcome in the process, we recommend an updated set of guidelines for providing presymptomatic genetic counseling and testing to people at high genetic risk for developing ALS. These recommendations are especially timely and relevant given the growing interest in studying presymptomatic ALS.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Researcher 4 12%
Student > Doctoral Student 3 9%
Student > Bachelor 3 9%
Lecturer 3 9%
Other 8 24%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 14 41%
Nursing and Health Professions 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Agricultural and Biological Sciences 2 6%
Psychology 2 6%
Other 2 6%
Unknown 10 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2018.
All research outputs
#672,257
of 13,583,786 outputs
Outputs from Neurology
#1,322
of 13,984 outputs
Outputs of similar age
#20,016
of 263,987 outputs
Outputs of similar age from Neurology
#53
of 247 outputs
Altmetric has tracked 13,583,786 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,984 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 247 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.