My intuition that non-linear effects add little beyond linear effects comes in part from this paper we published a few years back on utility of incorporating GxG and GxE terms in prediction models: https://t.co/qCwNkVg6nl 5/
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Epistasis may not account for "missing heritability" http://t.co/Sl441sAbtV or greatly improve risk prediction http://t.co/gx7Gs1bEuN
Connotea: Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Predict... http://t.co/YyyuqjLc
RT @moorejh: The @aliceparkny piece on the Kraft AJHG paper can be found here: http://t.co/RE4vCSZK. Kraft paper here: http://t.co/l3B5V ...
The @aliceparkny piece on the Kraft AJHG paper can be found here: http://t.co/RE4vCSZK. Kraft paper here: http://t.co/l3B5V80b #genetics
@WBUR interview about using #genetics to make disease risk predictions http://t.co/xRXFZkdx (paper: http://t.co/9nhI4HmK)
RT @TIMEHealthland: #Genetic tests are not as revealing as doctors hoped | http://t.co/owJjjfX9 (paper: http://t.co/9nhI4HmK)
RT @JediPD: GWAS unlikely to predict individual risks of complex disease. So There! Stop publicizing your genes! http://t.co/3QOVRMCX
GWAS unlikely to predict individual risks of complex disease. So There! Stop publicizing your genes! http://t.co/3QOVRMCX
Statistical geneticists like the story of gene-gene and gene-environment interactions. Is it fantasy? http://t.co/WbJdSABr @AJHGNews
New paper (http://t.co/9nhI4HmK) suggests that GxG & GxE intxns do not predict risk for complex diseases. Story: http://t.co/TdKYQTwf