RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @iamritu: Great thread on the lack of a good genetic instrument to understand bempedoic acid, inhibitor of ATP citrate lyase (ACLY), key…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @iamritu: Great thread on the lack of a good genetic instrument to understand bempedoic acid, inhibitor of ATP citrate lyase (ACLY), key…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/ybeHYG0VjK
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @iamritu: Great thread on the lack of a good genetic instrument to understand bempedoic acid, inhibitor of ATP citrate lyase (ACLY), key…
Great thread on the lack of a good genetic instrument to understand bempedoic acid, inhibitor of ATP citrate lyase (ACLY), key enzyme in cholesterol biosynthesis,now cleared for adults with heterozygous familial hypercholesterolemia or established ASCVD @T
Great thread on pitfalls with Mendelian randomization, in this case looking at a paper on ACLY gene (target of bempedoic acid). Good news is that we know from RCT that bempedoic acid reduces MACE!
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
RT @jpirruccello: In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not conv…
In 2019, a Mendelian randomization paper in @NEJM suggested that ACLY is a good drug target for LDL. I am still not convinced that it tells us anything about ACLY. https://t.co/uJdInLCKNw
So it makes sense that ACLY would be a good target for lowering cholesterol and preventing CV disease! And indeed - human genetics bear this out! https://t.co/VLJTZqACo3
RT @cardiomet_CE: 16) . . . through genetic variations in pathways that mimic #statins (#HMGCoA), #ezetimibe (#NCP1L1), #PCSK9 (monoclonals…
16) . . . through genetic variations in pathways that mimic #statins (#HMGCoA), #ezetimibe (#NCP1L1), #PCSK9 (monoclonals or #inclisiran), ACLY (bempedoic acid), results in similar differences in risk of #CHD. See 🔓https://t.co/TcKgTidix3 https://t.co/7qtf
@lenard_jakub not strange at all 😇 the Mendelian genetic studies show it all about life time exposure for example https://t.co/xiDphP2hER think of it like "pack years" this is why Familial Hyperlipidaemia causes early events
RT @skathire: Genetic variation in a 900,000 base region around ACLY gene (target of bempedoic acid), LDL-C, & risk for CAD Claim here: AC…
RT @skathire: Genetic variation in a 900,000 base region around ACLY gene (target of bempedoic acid), LDL-C, & risk for CAD Claim here: AC…
RT @skathire: Genetic variation in a 900,000 base region around ACLY gene (target of bempedoic acid), LDL-C, & risk for CAD Claim here: AC…
Update en #arteriosclerosi Dr @lluismasana Àcid bempedoic 📌 https://t.co/u7wl4SrnwI 📌 https://t.co/jTlfS1AeVR #22xula
大規模トライアルやからよんどけーと教授に言われた論文だが途中で諦めた https://t.co/XVrpTIA4mX https://t.co/I336iMCeGm
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/vikkEtyJJg
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @nutrepi: 論文1本ではその意義が伝わらない好例か・・ また時勢を読む巧さも・・🌸おそらく②の論文だけ浮いていたらNEJMには通らなかったでしょう。 https://t.co/Z9xeCNVeCd
RT @fumimamu: Great combination of RCT and genetic Mendelian randomisation, both supporting the important causal role of ATP citrate lyase…
Great combination of RCT and genetic Mendelian randomisation, both supporting the important causal role of ATP citrate lyase in lipid metabolism... Congrats, all including @cambridge_Uni, @PCU_Cambridge, ..💐
論文1本ではその意義が伝わらない好例か・・ また時勢を読む巧さも・・🌸おそらく②の論文だけ浮いていたらNEJMには通らなかったでしょう。 https://t.co/Z9xeCNVeCd
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/D2ZxobehAr
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/cTLZPyd2fX
RT @stevesphd: Using genetic variants to predict the outcome of a clinical trial (in the same journal edition as the trial itself). Shout o…
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM #ヒゲジャーナル https://t.co/8P6zvCSfrR
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
Really good analysis by @rplenge of Mendelian randomization study of bempedioc acid. I think it's in agreement with prior comments from @skathire. When comparing ACLY variants vs inhibition, imp to note that bemp has liver selective MOA (but idk how that
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @philippefroguel: Personnally I find the controversy on this paper excessive with some people overacting against the authors and @NEJM .…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
RT @skathire: Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from t…
Personnally I find the controversy on this paper excessive with some people overacting against the authors and @NEJM . A scientific debate is fine a mercyless wild war is not quite ethical even if some got divergent results on ADCLY. Keep cool colleagues
RT @rplenge: New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most…
A must-read
Terrific piece 👇🏽 from @rplenge on recent ACLY study (https://t.co/ytQEHpSbWS … …) Note: in large samples independent from the published study, we *cannot* replicate claim that "9-SNP ACLY genetic score" associates with coronary disease @NEJM should be
New https://t.co/k8qyHskEvk blog: a few thoughts on ADE PheWAS from recent @NEJM article on ACLY gene region. (Note that most of the @NEJM study was on MR to genetically validate ACLY; ADE PheWAS was a minor component of the study.) https://t.co/Jmp7NqWpES
RT @Prof_M_Ristow: Genetic variants that inhibit ATP citrate lyase #ACLY are associated with lower LDL #cholesterol levels in humans. #CVD…
RT @skathire: Genetic variation in a 900,000 base region around ACLY gene (target of bempedoic acid), LDL-C, & risk for CAD Claim here: AC…
Genetic variants that inhibit ATP citrate lyase #ACLY are associated with lower LDL #cholesterol levels in humans. #CVD #BempedoicAcid @EsperionInc https://t.co/TqJrAMOwoT https://t.co/TqJrAMOwoT
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/icr92OWIVN
RT @donsin4: #MendelianRandomization... a cool method for determining #genetic causality. How about using this method to identify #drug tar…
RT @donsin4: #MendelianRandomization... a cool method for determining #genetic causality. How about using this method to identify #drug tar…
RT @pnatarajanmd: Bempedoic acid (ACLY inhibitor) lowers LDL-C by ~19 mg/dl when added to max statin (https://t.co/p24rzwieWZ) and genetic…
RT @donsin4: #MendelianRandomization... a cool method for determining #genetic causality. How about using this method to identify #drug tar…
#MendelianRandomization... a cool method for determining #genetic causality. How about using this method to identify #drug targets in #COPD?
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
#Mendelian Randomization Study of #ACLY and #Cardiovascular #Disease | #NEJM https://t.co/mbH2co9TnO
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
Incidence of heat disease and stroke.?
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
$espr
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
Mendelian Randomization Study of ACLY and Cardiovascular Disease | NEJM https://t.co/m21hesTCRx
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…
RT @NEJM: Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol https://t.co/TGiLKLw6Bn Mendelian Randomization Study of ACLY an…