@clare__turnbull @iamslambert @timfrayling @carolinefwright @TheLancet @annekeluc @HelenVFirth @GeneticBill @mgtmccartney @Wilkie_Lab @RobinLachmann @group_tomlinson @lucymedgen In general autoimmune disease PRS have high discrimination that look quite pro
RT @DrRonaldMa1: Indeed exciting development in #T1DM and thanks @RAOram @mnweedon @ExeterMed Bill Hagopian and their teams for advancing t…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @DrRonaldMa1: Indeed exciting development in #T1DM and thanks @RAOram @mnweedon @ExeterMed Bill Hagopian and their teams for advancing t…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @DrRonaldMa1: Indeed exciting development in #T1DM and thanks @RAOram @mnweedon @ExeterMed Bill Hagopian and their teams for advancing t…
RT @DrRonaldMa1: Indeed exciting development in #T1DM and thanks @RAOram @mnweedon @ExeterMed Bill Hagopian and their teams for advancing t…
Indeed exciting development in #T1DM and thanks @RAOram @mnweedon @ExeterMed Bill Hagopian and their teams for advancing the field in this area and making early prediction of #T1DM and potential intervention a realistic strategy #precisionmedicine
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
RT @minouye271: PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -http…
PRS for type 1 diabetes have AUCs >0.90 & have potential to guide autoantibody testing in early childhood. Key papers -https://t.co/dEErH9Icwq -https://t.co/gyxt8ME0gr Exciting recent FDA approval of teplizumab-mzwv 👉 now an effective tool to delay
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
Now that there are treatments that can delay type 1 diabetes, it sounds like deployment of PRS could be useful today. Not sure if it is done today though
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
RT @minouye271: The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis…
The strongest polygenic risk scores I've seen are for autoimmune diseases, e.g. type 1 diabetes and ankylosing spongylitis (cuz HLA of course) Anyone seen another disease with PRS AUC~0.92-93 (or even better)? T1D paper https://t.co/dEErH9Icwq AS paper
Polygenic scores for diabetes (both types, despite different genetic architectures) are pretty good! https://t.co/gRFjV4sgAr https://t.co/eqqNvruxU2
@jwbelmon @JDRF @FerratLauric @ExeterMed @PNRIseattle @nature @UniofExeter genetic risk of T1D can be expressed as a continuous, near-normal distribution, so it is possible to select a cut off. We modelled the GRS element in this paper (https://t.co/AhWP24
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
RT @Hippoandfriends: Onderzoekers aan de Universiteit van Exeter (VK) en the Pacific Northwestern Research Institute in Seattle (USA) hebbe…
Onderzoekers aan de Universiteit van Exeter (VK) en the Pacific Northwestern Research Institute in Seattle (USA) hebben een nieuwe risicoscore ontworpen namelijk de T1DGRS2. Er wordt naar specifieke gebieden in het genoom... https://t.co/ynkYjouNHP
Check out the new genetic risk score used to screen for #Type1Diabetes — effective at screening & for cost-conscious screening. #T1D #EndoTwitter #FOAMed https://t.co/eZIbgIRiS2 https://t.co/dyfqbHlxMf
Genetic risk score highly useful for predicting T1 diabetes & improving newborn screening https://t.co/v3Lw1SYi3l @JDRF @ABCDiab @IntDiabetesFed @LDC_tweets @DiabetesUK @ADA_DiabetesPro @DiabetesCanada @AmDiabetesAssn @diabetesdaily @DiabetesMine @pa
@cecilejanssens @venkmurthy First as a technology. If it enables us to prevent T1D and other autoimmune entities, then it’ll definitely be transformative as well. And this is certainly not science fiction: https://t.co/5SLYouCYyw
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
RT @minouye271: For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celia…
For GRS/PRS skeptics, these high AUCs *are achievable* for autoimmune diseases. https://t.co/kDFK1mMMyS For example, celiac disease also has strong association with HLA. We & others have shown that AUCs of ~0.90 are achievable (eg via L1 regularized S
RT @em_saidwhat: Genetic risk scores for identifying newborns at high risk of developing #Type1diabetes: a link to the original publication…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
RT @minouye271: Author conclusions pretty much undeniable: GRS "is highly useful for classifying adult incident diabetes type and improving…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
RT @minouye271: GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.9…
Author conclusions pretty much undeniable: GRS "is highly useful for classifying adult incident diabetes type and improving newborn screening. Given the cost-effectiveness of SNP genotyping, this approach has great clinical and research potential in T1D" h
GRS for type 1 diabetes from @RAOram & the excellent Exeter team: - GRS of 67 snps & 18 HLA-DR/DQ haplotypes - AUC of 0.92 - AUC of 0.96 for early onset T1D (!) - Simulated newborn screening: 2x efficiency of HLA typing, 50% better than other G
RT @em_saidwhat: Genetic risk scores for identifying newborns at high risk of developing #Type1diabetes: a link to the original publication…
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis https://t.co/0TBzcJtGJG
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
Read exactly how @RAOram, @SethASharp and the team at @ExeterMed have developed a way of spotting newborns at high risk of #Type1diabetes using a new genetic risk score, in the full publication here: https://t.co/5W78DtSdj0
RT @em_saidwhat: Genetic risk scores for identifying newborns at high risk of developing #Type1diabetes: a link to the original publication…
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
Genetic risk scores for identifying newborns at high risk of developing #Type1diabetes: a link to the original publication below. Congrats again to @RAOram, @SethASharp and co. #ExeterDiabetes https://t.co/ZjKgNHU02M
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
RT @timfrayling: Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterd…
Improved T1 diabetes genetic risk score using 67 SNPs & 18 HLA haplotypes . by @SethASharp @mnweedon @RAOram #exeterdiabetes Will improve efficiency of prevention trials by increasing number of incident cases per $| Diabetes Care https://t.co/OS2X
RT @jmjvega: Development and Standardization of an Improved #Type1Diabetes Genetic Risk Score for Use in #NewbornScreening and Incident Dia…
Development and Standardization of an Improved #Type1Diabetes Genetic Risk Score for Use in #NewbornScreening and Incident Diagnosis | Diabetes Care https://t.co/SOC6wUglTN