| Title |
SEOM clinical guidelines in Hereditary Breast and ovarian cancer
|
|---|---|
| Published in |
Clinical and Translational Oncology, December 2015
|
| DOI | 10.1007/s12094-015-1435-3 |
| Pubmed ID | |
| Authors |
G. Llort, I. Chirivella, R. Morales, R. Serrano, A. Beatriz Sanchez, A. Teulé, E. Lastra, J. Brunet, J. Balmaña, B. Graña, On behalf of the SEOM Hereditary Cancer Working Group |
| Abstract |
Approximately, 7 % of all breast cancers (BC) and 11-15 % of ovarian cancers (OC) are associated with inherited predisposition, mainly related to germline mutations in high penetrance BRCA1/2 genes. Clinical criteria for genetic testing are based on personal and family history to estimate a minimum 10 % detection rate. Selection criteria are evolving according to new advances in this field and the clinical utility of genetic testing. Multiplex panel testing carries its own challenges and we recommend inclusion of genes with clinical utility. We recommend screening with annual mammography from age 30 and breast MRI from age 25 for BRCA1 and BRCA2 mutation carriers. Bilateral salpingo-oophorectomy should be offered to women with a BRCA1 or BRCA2 mutation, between 35 and 40 years and after completion of childbearing, or individualise based on the earliest age of ovarian cancer diagnosed in the family. Bilateral risk-reducing mastectomy is an option for healthy BRCA1 and BRCA2 mutation carriers, as well as contralateral mastectomy for young patients with a prior BC diagnosis. BRCA genetic testing in patients with BC and OC may influence their locoregional and systemic treatment. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 161 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 14% |
| Researcher | 21 | 13% |
| Other | 19 | 12% |
| Student > Ph. D. Student | 19 | 12% |
| Student > Doctoral Student | 14 | 9% |
| Other | 28 | 17% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 67 | 41% |
| Biochemistry, Genetics and Molecular Biology | 18 | 11% |
| Agricultural and Biological Sciences | 10 | 6% |
| Nursing and Health Professions | 5 | 3% |
| Social Sciences | 4 | 2% |
| Other | 17 | 10% |
| Unknown | 41 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2019.
All research outputs
#14,247,377
of 22,844,985 outputs
Outputs from Clinical and Translational Oncology
#594
of 1,305 outputs
Outputs of similar age
#204,204
of 390,205 outputs
Outputs of similar age from Clinical and Translational Oncology
#13
of 26 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,305 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 390,205 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.