Title |
Genomic Epidemiology of Global Carbapenemase-Producing Enterobacter spp., 2008–2014 - Volume 24, Number 6—June 2018 - Emerging Infectious Diseases journal - CDC
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Published in |
Emerging Infectious Diseases, June 2018
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DOI | 10.3201/eid2406.171648 |
Pubmed ID | |
Authors |
Gisele Peirano, Yasufumi Matsumura, Mark D. Adams, Patricia Bradford, Mary Motyl, Liang Chen, Barry N. Kreiswirth, Johann D.D. Pitout |
Abstract |
We performed whole-genome sequencing on 170 clinical carbapenemase-producing Enterobacter spp. isolates collected globally during 2008-2014. The most common carbapenemase was VIM, followed by New Delhi metallo-β-lactamase (NDM), Klebsiella pneumoniae carbapenemase, oxacillin 48, and IMP. The isolates were of predominantly 2 species (E. xiangfangensis and E. hormaechei subsp. steigerwaltii) and 4 global clones (sequence type [ST] 114, ST93, ST90, and ST78) with different clades within ST114 and ST90. Particular genetic structures surrounding carbapenemase genes were circulating locally in various institutions within the same or between different STs in Greece, Guatemala, Italy, Spain, Serbia, and Vietnam. We found a common NDM genetic structure (NDM-GE-U.S.), previously described on pNDM-U.S. from Klebsiella pneumoniae ATCC BAA-214, in 14 different clones obtained from 6 countries spanning 4 continents. Our study highlights the importance of surveillance programs using whole-genome sequencing in providing insight into the molecular epidemiology of carbapenemase-producing Enterobacter spp. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 50% |
Australia | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 114 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 18% |
Student > Ph. D. Student | 12 | 11% |
Student > Master | 12 | 11% |
Student > Doctoral Student | 9 | 8% |
Student > Bachelor | 7 | 6% |
Other | 20 | 18% |
Unknown | 33 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 19 | 17% |
Medicine and Dentistry | 17 | 15% |
Immunology and Microbiology | 15 | 13% |
Agricultural and Biological Sciences | 8 | 7% |
Chemistry | 4 | 4% |
Other | 12 | 11% |
Unknown | 39 | 34% |