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Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer

Overview of attention for article published in Cancer (0008543X), March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

blogs
1 blog

Citations

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158 Dimensions

Readers on

mendeley
166 Mendeley
Title
Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer
Published in
Cancer (0008543X), March 2015
DOI 10.1002/cncr.29364
Pubmed ID
Authors

Hideaki Kinugasa, Kazuhiro Nouso, Koji Miyahara, Yuki Morimoto, Chihiro Dohi, Koichiro Tsutsumi, Hironari Kato, Takehiro Matsubara, Hiroyuki Okada, Kazuhide Yamamoto

Abstract

Cell-free circulating tumor DNA (ctDNA) in serum has been considered to be a useful candidate for noninvasive cancer diagnosis. The current study was designed to estimate the clinical usefulness of genetic analysis for ctDNA by digital polymerase chain reaction in patients with pancreatic cancer. The authors compared K-ras mutations detected in endoscopic ultrasound-guided fine-needle aspiration biopsy tissue DNA and in ctDNA from 75 patients with pancreatic cancer. K-ras mutations in the serum of 66 independent, consecutive patients with pancreatic cancer were also analyzed and the authors compared the results with survival rates. The frequencies of the mutations in tissue samples at G12V, G12D, and G12R in codon 12 were 28 of 75 samples (37.3%), 22 of 75 samples (29.3%), and 6 of 75 samples (8.0%), respectively. Conversely, the rates of the mutations in ctDNA were 26 of 75 samples (34.6%), 29 of 75 samples (38.6%), and 4 of 75 samples (5.3%), respectively. Overall, the K-ras mutation rates in tissue and ctDNA were 74.7% and 62.6%, respectively, and the concordance rate between them was 58 of 75 samples (77.3%). Survival did not appear to differ by the presence of K-ras mutations in tissue DNA, but the survival of patients with K-ras mutations in ctDNA was significantly shorter than that of patients without mutations in both a development set (P = .006) and an independent validation set (P = .002). The difference was especially evident in cases with a G12V mutation. Analysis of ctDNA is a new useful procedure for detecting mutations in patients with pancreatic cancer. This noninvasive method may have great potential as a new strategy for the diagnosis of pancreatic cancer as well as for predicting survival. Cancer 2015. © 2015 American Cancer Society.

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ukraine 1 <1%
Germany 1 <1%
Ireland 1 <1%
Unknown 163 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 21%
Researcher 25 15%
Student > Master 23 14%
Student > Bachelor 16 10%
Student > Doctoral Student 13 8%
Other 29 17%
Unknown 25 15%
Readers by discipline Count As %
Medicine and Dentistry 50 30%
Biochemistry, Genetics and Molecular Biology 36 22%
Agricultural and Biological Sciences 32 19%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Engineering 5 3%
Other 9 5%
Unknown 29 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2015.
All research outputs
#2,703,806
of 12,177,765 outputs
Outputs from Cancer (0008543X)
#2,801
of 9,206 outputs
Outputs of similar age
#52,550
of 219,346 outputs
Outputs of similar age from Cancer (0008543X)
#81
of 199 outputs
Altmetric has tracked 12,177,765 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,206 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.3. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 199 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.