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Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer

Overview of attention for article published in Clinical Cancer Research, November 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
20 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
70 Dimensions

Readers on

mendeley
134 Mendeley
Title
Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer
Published in
Clinical Cancer Research, November 2017
DOI 10.1158/1078-0432.ccr-17-2092
Pubmed ID
Authors

Giovanna Rossi, Zhaomei Mu, Alfred W. Rademaker, Laura K. Austin, Kimberly S. Strickland, Ricardo Lima Barros Costa, Rebecca J. Nagy, Vittorina Zagonel, Timothy J. Taxter, Amir Behdad, Firas H. Wehbe, Leonidas C. Platanias, William J. Gradishar, Massimo Cristofanilli

Abstract

Liquid biopsy provides a real-time assessment of metastatic breast cancer (MBC). We evaluated the utility of combining circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) to predict prognosis in MBC. We conducted a retrospective study of 91 patients with locally advanced and MBC. CTCs were enumerated by CellSearch; the plasma-based assay was performed utilizing Guardant360TM and the survival analysis using Kaplan-Meier curves. 84 patients had stage IV cancer, 7 had no metastases. Eighty patients had CTCs analysis: median number 2 (0-5612). 232/277 (84%) blood samples had mutations. The average ctDNA fraction was 4.5% (0-88.2%) and number of alterations 3 (0-27); the most commonly mutated genes: TP53 (52%), PIK3CA (40%), ERBB2 (20%). At the time of analysis 36 patients (39.6%) were dead. The median follow-up for CTCs was 9 months; for ctDNA 9.9 months. For CTCs and ctDNA respectively, PFS was 4.2 and 5.2 months and OS was 18.7 and 21.5 months. There was a statistically significant difference in PFS and OS for baseline CTCs  < 5 versus CTCs ≥ 5 (p = 0.021 and p = 0.0004 respectively); % ctDNA < 0.5 versus ≥ 0.5 p = 0.003 and p = 0.012); number of alterations < 2 versus ≥ 2 (p = 0.059 borderline and p= 0.0015). A significant association by Fisher's exact test was found between the number of alterations and the % ctDNA in the baseline sample p < 0.0001). The study demonstrated that liquid biopsy is an effective prognostic tool.

Twitter Demographics

The data shown below were collected from the profiles of 20 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 134 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 16%
Researcher 21 16%
Student > Bachelor 16 12%
Other 14 10%
Student > Master 12 9%
Other 23 17%
Unknown 27 20%
Readers by discipline Count As %
Medicine and Dentistry 40 30%
Biochemistry, Genetics and Molecular Biology 31 23%
Agricultural and Biological Sciences 11 8%
Engineering 8 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 6 4%
Unknown 34 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2018.
All research outputs
#933,751
of 17,367,552 outputs
Outputs from Clinical Cancer Research
#637
of 11,148 outputs
Outputs of similar age
#32,750
of 419,631 outputs
Outputs of similar age from Clinical Cancer Research
#22
of 201 outputs
Altmetric has tracked 17,367,552 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,148 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,631 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.