@josephbush @PharmRJ Read this instead https://t.co/lrQzaXSf2M
@JacobGudiol @AgnesWold Sedan finns också andra typer av studier som talar emot de nyttiga effekterna (vilka nog få skulle se som anledning att börja dricka i vilket fall). https://t.co/NLujbIMy4B
@TAH_Sci @VPrasadMDMPH Yep .. again, and again, and again https://t.co/5lBAsCH1Zo https://t.co/yaZSCoIrns https://t.co/DroMfM1ygn & https://t.co/yKeXqrGqhc
RT @maneiroruben: Estupefacto. Falta de conocimiento de las últimas evidencias o presión de ciertos lobbies? Los datos tumban esta desafo…
Estupefacto. Falta de conocimiento de las últimas evidencias o presión de ciertos lobbies? Los datos tumban esta desafortunada opinión 👇🏼 https://t.co/hWmLlLVkfK https://t.co/4SsFO34cMe
@fernandodg9991x @LUH_noticias @IdiazAyuso A ver, imbecil, que yo no te falté al respeto. Te paso información de fuentes mas fiables, ya que veo que tu no eres capaz. Te lo resumo, el acohol es malo. https://t.co/vyU2hb7ngc https://t.co/TTsAsAU1qy https://
酒は百薬の長って誰が言ったんだよ https://t.co/jdjW9mL8l5
RT @adammartinsk: No és bo per al cor. "Reduir el consum d'alcohol, fins i tot en quantitats petites o moderades, és BENEFICIÓS la salut ca…
No és bo per al cor. "Reduir el consum d'alcohol, fins i tot en quantitats petites o moderades, és BENEFICIÓS la salut cardiovascular" (estudi fet amb dades de més de 250.000 persones). https://t.co/jRZR2FD8Nq
@ScepticalDoctor @jerryteixeira You should read section "Principal findings of study": https://t.co/SMsDyfFsGp https://t.co/07ngyyqsnH
Some confirmation of a @ScottAdamsSays hypothesis: A Mendelian randomization analysis suggests “reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.” https://t.co/ZKJgoqPvyp
@JosephTalinax @ZK_ZK100 @cbotha32 @GunFreeSA Less is always better for alcohol and heart health: Holmes, M. et al (2014). Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ (C
@M_Stamatakis I may live in a bubble, but I don’t know anyone who thinks alcohol prevents CVD. The genetic/IV field has been on this for a while: https://t.co/44uZFHInHv https://t.co/l6qrGPfrqE https://t.co/OMZACXf9OJ https://t.co/nJi1bldP5A
@sebrushworth On the same topic - interesting results from the latest Mendelian randomisation analyses also pointing in these directions. https://t.co/JnOy1oktVy
No, no es verdad. Todo lo contrario El alcohol es neurotóxico y perjudicial para el sistema cardiovascular. Sea la cantidad que sea: https://t.co/hWmLlLVkfK Y no, tampoco adelgaza. El alcohol aporta muchísimas calorías de nulo valor nutricional. Por fav
@HerranAitor @Rikitoti8 https://t.co/MYp4ajlh5W Por ejemplo este.
Previous studies have shown a monotone increasing association between genetically-predicted alcohol consumption and stroke in a Chinese study (https://t.co/gpas1o2dov), and with heart disease risk in a Western population based on a single variant (https://
@drpaulkasenene This remains a controversial topic unfortunately. This Mendelian Randomisation study suggests that reducing alcohol even in mild and moderate drinkers might be beneficial to cardiovascular health. https://t.co/Beq1GrdmIx https://t.co/fllp
@adribaran @PrashSanders @EPWoodsShop @Ed_Gerst @drraviele @drjohnm @EricTopol @Dominik_Linz @mariofitzm @asosaliprandi @Vosko1984 Here you have the full version https://t.co/lioxbSf6iK And if we go to Mendelian randomization, alcohol reduction for cardiov
RT @drmiguelmarcos: @EricTopol @theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet Thanks for disclosing your conflict of interest…
RT @drmiguelmarcos: @EricTopol @theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet Thanks for disclosing your conflict of interest…
@EvaAnyon @EricTopol @theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet @GT_Alcohol_SEMI Thanks. Thanks for disclosing your conflict of interest 😅. Mendelian randomization has emphasized the toxic effect of ethanol and not found the potential ben
@EricTopol @theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet Thanks for disclosing your conflict of interest 😅. Mendelian randomization has emphasized the toxic effect of ethanol and not found the potential benefits https://t.co/LEC3e5gfx8 http
@waltzing_piglet 1. No podemos predecir el riesgo. 2. Las aproximaciones, como la randomización mendeliana, ponen de manifiesto el efecto tóxico del alcohol (sin beneficios...) https://t.co/LEC3e5gfx8 https://t.co/4SPJ9u8kgA https://t.co/ZWSSrSkUeH 3. Conf
@s8mb @Jandrade0112 @karlbykarlsmith It's not new evidence, it's well supported by very large studies that there are no benefits to drinking. https://t.co/wGSPYkzx7W The J curve can be explained away very easily by socio-economic factors.
@adribaran @SAC_54 Ya se ha usado y no es un RCT sino un observacional porque no hay intervención. Pero me alegra que lo mencione por esto: “ This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardio
And here is possibly a little incentive to relax a little this weekend in prep for SWOTVAC @TessTsindos @PennyRobaus @Monash_SPHPM https://t.co/6923YNEfzv
@robinhanson @bswud And to the unanswered responses to the article here listed? https://t.co/jXVTRqVM5c
@EricCrampton @robinhanson There are also IV studies via Mendelian randomisation now https://t.co/CeO0Lb3Zdf
@Mangan150 largely discredited by recent research using stronger designs, showing no protective effect of moderate drinking (i.e., no U-shape dose-outcome association ) https://t.co/UIm1zDAC7e
@Dr_A_Johnstone @Smith_N_M @BrewDog @pintofscience If youre interested,i felt this was a good explanation of alcohol-health assocs: https://t.co/CLaMXciAkW More science-y sources: https://t.co/vsWsPcI3tI https://t.co/rYl8zRMpxW https://t.co/woQTv69LQM Thi
RT @mvholmes: Using MR, our best efforts in Europeans suggested that alcohol doesn’t protect from heart disease, but the genetic variant on…
Using MR, our best efforts in Europeans suggested that alcohol doesn’t protect from heart disease, but the genetic variant only led to a 17% difference in alcohol intake, which posed a challenge to extrapolate across the distribution of alcohol intake http
@cjsnowdon This replicates findings from a study of adults of European descent published in 2014: https://t.co/SqZeWjKYRE
RT @DrLJx: @Dr_C_Llewellyn Definitely challenging. But I wondered if it's important that most drinks consumed in this population were spiri…
RT @DrLJx: @Dr_C_Llewellyn Definitely challenging. But I wondered if it's important that most drinks consumed in this population were spiri…
RT @DrLJx: @Dr_C_Llewellyn Definitely challenging. But I wondered if it's important that most drinks consumed in this population were spiri…
@Dr_C_Llewellyn Definitely challenging. But I wondered if it's important that most drinks consumed in this population were spirit based? #cognitivedissonance Sadly not according to @mvholmes 2014 IPD-MR of alcohol & CHD in 56 international studies http
@ecosdelfuturo @Rinascita92 @RadiactivoMan https://t.co/lxQ4b7J4gl https://t.co/HGXzqzaXVx https://t.co/Dh71xNpkpn Pues parece que algún riesgo sí que tiene. La pregunta es ¿por qué beber alcohol? Sabiendo que sus supuestos beneficios son mentira y sabien
@mjjoe4 @drmiguelmarcos @cubic_logic This is great point, because mendelian randomization has shown NO benefit of moderate or low dose etanol with cardiovascular disease. Another point for advocates of reducing etanol intake, thank you. https://t.co/y1YJKY
RT @vik_bajaj: If reading or reporting on the GBD alcohol paper (https://t.co/4XSd5KM4tj) you could look at studies employing methods from…
(v) CVD is the biggest killer in the world. Randomized evidence from human genetics supports more alcohol being deleterious to risk factors causal in CVD and to CHD risk itself https://t.co/ackmavINzn
RT @vik_bajaj: If reading or reporting on the GBD alcohol paper (https://t.co/4XSd5KM4tj) you could look at studies employing methods from…
RT @vik_bajaj: If reading or reporting on the GBD alcohol paper (https://t.co/4XSd5KM4tj) you could look at studies employing methods from…
If reading or reporting on the GBD alcohol paper (https://t.co/4XSd5KM4tj) you could look at studies employing methods from causal inference (e.g. Mendelian randomization, incl. https://t.co/Di1225TupF, https://t.co/CZ5VI24G80) to alcohol & cardiovascu
@guardianscience "studies repeatedly produced graphs with a J-shaped curve, showing both abstinence and excessive consumption associated with the worst health outcomes"..but ↑ risk in abstainers oft attributed to "sick quitter" bias.strong argument against
@JuhanaHarju @PekkaPuska1 @Jocka @bonusmaxi @PhilipRelander @JanneViinikkala @LeenasEyez Toinen samaan viittava: https://t.co/fiNIHzXVxM
@mkeulemans @michelvanbaal @Chem2W @DiederikJekel @govertschilling @MarkvLoosdrecht @RoyMeijer Het persbericht van Erasmus MC heb ik niet gezien. Wel dat van de Lancet. Dat klopte volgens mij. Het idee dat matig drinken goed is voor het hart was al eerder
@cecilejanssens @LudoAmelsvoort Die beperkingen worden zeker wel onderkend. De totaliteit van het bewijs (experimenteel en observationeel) is de basis voor aanbevelingen. Ook Mendelian randomization wijst overigens op verband weinig drinken en minder risic
RT @mvholmes: @skathire @MorganPfiffner @mendel_random there's one under review using powerful genetic instruments that will add +++ to thi…
RT @mvholmes: @skathire @MorganPfiffner @mendel_random there's one under review using powerful genetic instruments that will add +++ to thi…
@skathire @MorganPfiffner @mendel_random there's one under review using powerful genetic instruments that will add +++ to this area, but here are some published examples for vascular risk factors & disease (others exist): https://t.co/gavhWfY9LX https:
@skathire @jeet_mahal @MarkELindsay @ethanjweiss @cecilejanssens @VinayPrasadMD @UniCambridge @f2harrell No doubt evidence from Mendelian randomization studies using kadoorie / uk Biobank just around the corner (easier to do in East Asia where adh1b varian
@isdatzo1 Observationele studies hebben natuurlijk beperkingen als het gaat om vaststellen causaliteit. Die beperkingen zijn sterk verminderd bij Mendelian randomization. Ook dan blijkt matig drinken geassocieerd met een verhoogd risico op hart- en vaatzie
RT @mvholmes: Alternatively - keep the trial running long enough to show the harmful effects of alcohol on BMI and SBP which would then lin…
Alternatively - keep the trial running long enough to show the harmful effects of alcohol on BMI and SBP which would then line up nicely with our findings reported here https://t.co/ackmavINzn and in other genetic studies (but agree sounds like the trial
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data https://t.co/1RVWXi5Hyg
@Looping_ désolé 😬... pour le cp, pr préparer le dossier,j'ai appris plein de trucs, notammnt avec la méthodo de cette xp https://t.co/J4ibEULcMU, ms c'était un peu chaud à expliquer... ...mais oui, c'était plus une réponse à ceux qui font 🙈🙉🙊,et la m-à-j
@speedygonzalez @pezcharles También hay estudios que no lo confirman https://t.co/Hu9MeiGL7d https://t.co/YMyC9XF3rP https://t.co/Xsn7hkse2O En uno está la explicación de uno de los posibles sesgos, como bien apunta @pezcharles En concreto el "absteiner bi
@ArtirKel otro observacional de nutrición, cuya cobertura mediática ya llamé a abolir previamente https://t.co/tuNtTObzKd https://t.co/n6FsihGTqg https://t.co/FIi5SvDfGw https://t.co/a6GXuF0VPk
@skathire @DrMJoyner @VinayPrasad82 @EricTopol @jgreid @cecilejanssens @stephensenn .... not that these MR examples are useful for prediction - but reliable G*E do exist in CVD. Eg https://t.co/wPglQgePg7 and https://t.co/PrP9ghIgjv (not exhaustive by any
@virosta_cat I tant. https://t.co/EbuCySbsRt https://t.co/ZVs6G1w4gl Però llegeix això: https://t.co/KZSLLugPl7
@bonusmaxi Niin, katso tämä myös, kyllä siinä alkaa konsensusta jo olemaan: https://t.co/PlwsE667IZ
@bonusmaxi Tämä BMJ:n juttu noin 260 000 ihmisen aineistolla päätyi siis samansuuntaisiin havantoihin: ei hyötyä. Aika monta tutkijaa tekijöinä, ei huvita kopioida tähän mutta voin toki jos haluat: https://t.co/PlwsE667IZ
RT @GT_Alcohol_SEMI: @exitus_lethalis @juan_revenga @JulioBasulto_DN @educacion_papps Hay nuevos modelos experimentales.P. ej., usando la a…
@exitus_lethalis @juan_revenga @JulioBasulto_DN @educacion_papps Hay nuevos modelos experimentales.P. ej., usando la aleatorización mendeliana también se reduce el posible beneficio https://t.co/k2Orlvls3j
@NHSG_HWL Consume less alcohol have lower risk of heart disease. Lower alcohol consumption is good for health. #worldheartday https://t.co/mSVLIRtOFg https://t.co/74e8CRaiMg
People who consume less alcohol have lower risk of heart disease & stroke. Lower alc consumption is good for health. https://t.co/mSVLIRtOFg https://t.co/HuLvOpSpFC
@DailyMirror @MiriamStoppard US Heart & Stroke Assns dont encourage alcohol: Redn of moderate alcohol consumption is beneficial for heart health https://t.co/mSVLIRtOFg
@clarketk2 @mcintosh2001 @Used_For_Glue @LS_Hall @mja It certainly is in contrast to the MR estimates from other sources e.g. https://t.co/tfuaHso7PF and https://t.co/wPglQgePg7 2/n
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
@skathire @mendel_random @mvholmes has a nice MR paper in BMJ suggesting that drinking (even moderate) increases CHD risk https://t.co/VCunZJhkUY
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
RT @mvholmes: Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
Think there might be a clue somewhere in this study: https://t.co/wPglQgePg7 https://t.co/ADh4xJN7yt
@Sir_Stinson @JulioBasulto_DN Te dejo esto por aquí. https://t.co/pHTyJdiDti https://t.co/M302h9iLml
Association alcohol & cardiovascular disease: Mendelian randomisation analysis based on individual participant data https://t.co/RSaO2stxe4
Twin epidemiology (note effect size vs non-twin cohorts): https://t.co/NBAK2WZdh0 ; Mendelian Randomization: https://t.co/nbOEzx0vOq
@Minervanett @jasnoen spenstig bruk av ordet "bekrefter". hva med denne meta-analysen med genetisk epidemiologi? https://t.co/cQRIJSKPyV
@GadAbraham1 or alternatively stratify by exposure (nb: collider bias alert!) as in figure 2 of our paper here: https://t.co/h2k1XjvIOB
@ethanjweiss @ErikIngelsson @skathire funny you should ask: https://t.co/wPglQgePg7
Association between alcohol and cardiovascular disease:https://t.co/UeMODEYvmq
@JHolmesSheff @cjsnowdon and this is pretty convincing evidence against any protective effect or *debunking* https://t.co/RNYoWjJGx0
RT @david_colquhoun: But J-shaped curve for wine is probably a result of confounders https://t.co/TDQxe1GWlX (contrary to Spiked's view) ht…
But J-shaped curve for wine is probably a result of confounders https://t.co/TDQxe1GWlX (contrary to Spiked's view) https://t.co/jOXI8EgKCH
@aaronecarroll @UpshotNYT what about mendelian randomisation studies suggesting increased CHD in moderate drinkers? https://t.co/N70QCMLaiB
@tslumley @TheAtavism I've also found the commentary on this one to be useful. https://t.co/XHc82umpwF