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Assessing the cost of implementing the 2011 Society of Obstetricians and Gynecologists of Canada and Canadian College of Medical Genetics practice guidelines on the detection of fetal aneuploidies

Overview of attention for article published in Prenatal Diagnosis, August 2017
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Title
Assessing the cost of implementing the 2011 Society of Obstetricians and Gynecologists of Canada and Canadian College of Medical Genetics practice guidelines on the detection of fetal aneuploidies
Published in
Prenatal Diagnosis, August 2017
DOI 10.1002/pd.5112
Pubmed ID
Authors

Margaret Lilley, Stacey Hume, Nina Karpoff, Georges Maire, Sherry Taylor, Robert Tomaszewski, Maisa Yoshimoto, Susan Christian

Abstract

The Society of Obstetricians and Gynecologists of Canada (SOGC) and the Canadian College of Medical Genetics (CCMG) published guidelines, in 2011, recommending replacement of karyotype with QF-PCR when prenatal testing is performed because of an increased risk of a common aneuploidy. This study's objective is to perform a cost analysis following the implementation of QF-PCR as a stand-alone test. A total of 658 samples were received between April 1, 2014 and August 31, 2015: 576 amniocentesis samples and 82 CVS. A chromosome abnormality was identified in 14% (93/658) of the prenatal samples tested. The implementation of the 2011 SOGC-CCMG guidelines in Edmonton and Northern Alberta resulted in a cost savings of $46,295.80. The replacement of karyotype with chromosomal microarray (CMA) for some indications would be associated with additional costs. The implementation of new test methods may provide cost savings or added costs. Cost analysis is important to consider during the implementation of new guidelines or technologies.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 20%
Student > Postgraduate 2 20%
Other 2 20%
Researcher 1 10%
Unknown 3 30%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Biochemistry, Genetics and Molecular Biology 2 20%
Nursing and Health Professions 1 10%
Economics, Econometrics and Finance 1 10%
Arts and Humanities 1 10%
Other 0 0%
Unknown 3 30%