VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans

@JustinTaylorLab Recommend Harry Greenberg’s work looking at rotavirus specific B cells in intestinal biopsies https://t.co/sRGqi7rKYz Also @SalliePermar’s work pulling HIV specific B cells from colostrum https://t.co/DHp5hGyZW7

We wanted to put this mAb into lactating mice; so we had to make a chimera. Our IgA had to bind *mouse* pIgR so we used mouse J chain + IgA Fc. But we wanted the Fab to bind human rotavirus, so we used Fab sequences from H Greenberg (the OG rotavirologist)

RT @drbrainbugz: Humans generate heterotypic neutralising antibody responses to rotaviruses to circumvent their serotypic diversity: https:…

RT @drbrainbugz: Humans generate heterotypic neutralising antibody responses to rotaviruses to circumvent their serotypic diversity: https:…

RT @drbrainbugz: Humans generate heterotypic neutralising antibody responses to rotaviruses to circumvent their serotypic diversity: https:…

Humans generate heterotypic neutralising antibody responses to rotaviruses to circumvent their serotypic diversity: https://t.co/Om6vkYEusC

RT @infdisease_news: VP4- & VP7-Specific Antibodies Mediate Heterotypic Immunity to Rotavirus in Humans @cdcgov @StanfordMed https://t.co/f…

VP4- & VP7-Specific Antibodies Mediate Heterotypic Immunity to Rotavirus in Humans @cdcgov @StanfordMed https://t.co/fU2CBnGJA2

VP4- and VP7-specific antibodies mediate heterotypic immunity to #rotavirus in humans https://t.co/tIawFKfhaF

VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans. https://t.co/IyokvugXtY #SciTranslMed

VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans. https://t.co/oUZWEIB6HT https://t.co/gpCqaIrxfj

Study from @stanfordmed offers new insight into why one rotavirus vaccine protects against multiple strains https://t.co/gS3X5Ak55R https://t.co/MDCacvAotd

[Research Articles] VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans https://t.co/TOUetzQsPx