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Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

Overview of attention for article published in Clinical Pharmacology & Therapeutics, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
2 blogs
twitter
11 tweeters
patent
4 patents

Citations

dimensions_citation
471 Dimensions

Readers on

mendeley
386 Mendeley
Title
Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
Published in
Clinical Pharmacology & Therapeutics, January 2014
DOI 10.1038/clpt.2013.254
Pubmed ID
Authors

K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam, C A Prows, E D Kharasch, T C Skaar

Abstract

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 genotype. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 386 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Brazil 3 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
Switzerland 1 <1%
Unknown 376 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 68 18%
Student > Master 57 15%
Student > Bachelor 53 14%
Student > Ph. D. Student 42 11%
Other 30 8%
Other 85 22%
Unknown 51 13%
Readers by discipline Count As %
Medicine and Dentistry 90 23%
Biochemistry, Genetics and Molecular Biology 73 19%
Pharmacology, Toxicology and Pharmaceutical Science 68 18%
Agricultural and Biological Sciences 56 15%
Nursing and Health Professions 9 2%
Other 29 8%
Unknown 61 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2020.
All research outputs
#1,040,125
of 18,038,980 outputs
Outputs from Clinical Pharmacology & Therapeutics
#146
of 3,715 outputs
Outputs of similar age
#14,926
of 266,033 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#3
of 25 outputs
Altmetric has tracked 18,038,980 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,715 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,033 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.