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Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

Overview of attention for article published in Clinical Pharmacology & Therapeutics, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
patent
2 patents
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
245 Dimensions

Readers on

mendeley
231 Mendeley
citeulike
1 CiteULike
Title
Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing
Published in
Clinical Pharmacology & Therapeutics, August 2013
DOI 10.1038/clpt.2013.172
Pubmed ID
Authors

K E Caudle, C F Thorn, T E Klein, J J Swen, H L McLeod, R B Diasio, M Schwab

Abstract

The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene), and reduced or absent activity of this enzyme can result in severe, and sometimes fatal, toxicity. We summarize evidence from the published literature supporting this association and provide dosing recommendations for fluoropyrimidines based on DPYD genotype (updates at http://www.pharmgkb.org).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 231 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 <1%
United States 1 <1%
Spain 1 <1%
Unknown 227 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 16%
Student > Master 32 14%
Student > Ph. D. Student 27 12%
Other 27 12%
Student > Bachelor 19 8%
Other 64 28%
Unknown 25 11%
Readers by discipline Count As %
Medicine and Dentistry 84 36%
Agricultural and Biological Sciences 35 15%
Biochemistry, Genetics and Molecular Biology 33 14%
Pharmacology, Toxicology and Pharmaceutical Science 27 12%
Nursing and Health Professions 4 2%
Other 12 5%
Unknown 36 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2020.
All research outputs
#1,278,218
of 17,351,915 outputs
Outputs from Clinical Pharmacology & Therapeutics
#175
of 3,618 outputs
Outputs of similar age
#19,510
of 271,328 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#1
of 13 outputs
Altmetric has tracked 17,351,915 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,618 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,328 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.