@doctorveera @hakyim Regarding ERAP1, you may be interested in taking a look at our pGWAS with @SomaLogic where we found that two previously identified ankylosing spondylitis-risk variants associated, in an additive manner, with levels of circulating ERA
@jochwenk @SomaLogic @String White blood cell leakage is indeed an important source of variation. We saw it in our #proteomics GWAS https://t.co/mvHiPXae0c where the first principal component mirrored this effect with HSP90 as one possible proxy. But how w
RT @ksuhre: @damato_mauro @ProfJohnATodd @NatureGenet @lukejostins Any news in overlap with #proteomics #QTL ? We saw quite a bit in a smal…
@damato_mauro @ProfJohnATodd @NatureGenet @lukejostins Any news in overlap with #proteomics #QTL ? We saw quite a bit in a smaller study https://t.co/7hFeRrTYNB - see Fig 1c in https://t.co/mvHiPX9GaE
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
A few years ago @ksuhre and colleagues conducted a protein QTL GWAS in several cohorts. Among other things they found a trans-pQTL at the TRIM58 locus affecting levels of a dyneine light chain protein (DYNLRB1) thus confirming a link between the two: htt
@tomkXY @jgschraiber Yes - a #proteomics GWAS, initially on genotyped variants only, then refined #pQTL s using imputed data. Much stronger hits found on imputed SNPs, as shown here. Genotyped lead SNP (P=1E-108), imputed (P=4E-179). Details at https://t.c
Replication in the multi-ethnic QMDiab study, with 1,129 protein measurements from the @SomaLogic v1.3 kit measured in 356 plasma samples. The QMDiab #proteomics data has been used in a GWAS https://t.co/mvHiPX9GaE and an EWAS https://t.co/qIwoQZYkUO with
RT @B_A_Benitez: Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organize…
RT @B_A_Benitez: Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organize…
RT @B_A_Benitez: Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organize…
RT @B_A_Benitez: Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organize…
RT @B_A_Benitez: Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organize…
Superb webinar on #Proteomics, the missing link between #GWAS, EWAS, & disease endpoints by Dr. @ksuhre @WCMQatar organized by @SomaLogic. Data available at @NatureComms https://t.co/Nhvo9HBR3R & https://t.co/XeNSwqWUVP plus an updated #metabolomic
Looking forward to this webinar by the always entertaining @ksuhre later today!
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
Connecting genetic risk to disease endpoints through the human blood plasma proteome published as: https://t.co/0cRALwlufL @naturecomms #biorxiv
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
RT @ksuhre: Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic pl…
Please join me for my upcoming webinar on genome-wide #GWAS and epigenome-wide #EWAS association studies with the @SomaLogic platform, both recently published in @NatureComms : https://t.co/mvHiPX9GaE & https://t.co/qIwoQZYkUO
@ivivek87 @jwbelmon @EpgntxEinstein @EpiEllie @venkmurthy @f2harrell @MaartenvSmeden I hope we explained everything - we used inverse normal scaling as a more robust, but statistically less powerful approach to avoid spurious associations - just as we did
RT @ksuhre: Just realized: a TMT-MS study in human iPSC cells replicates several of our https://t.co/mvHiPX9GaE pQTLs with @SomaLogic in bl…
Just realized: a TMT-MS study in human iPSC cells replicates several of our https://t.co/mvHiPX9GaE pQTLs with @SomaLogic in blood, incl CPNE1 (https://t.co/xR07Wi7rfT) and ERAP1 (https://t.co/cpdh94xkQs): see Tab S7 of @biorxiv_genetic paper https://t.co/
Such an exciting talk by @ksuhre today!! Inspirational
Soon. For #metabolomics I hope :) Will add so much to our current understanding!
Big news indeed - but when will we go beyond genomics at this scale, and invest in full blown #metabolomics and #proteomics - so much to gain - see https://t.co/AmJXOJpPhE and https://t.co/mvHiPX9GaE
@GlycomicsExpasy some evidence can come from proteomics GWAS - the ABO locus has three pleiotropic pQTLs, some (many?) of which may be driven by glyco-epitope effects .. read more here: https://t.co/Yk1uv1O106
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
RT @ksuhre: Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - h…
Impressive Proteome PheWAS browser - provides #Mendelian #Randomization of thousands proteins against hundreds of disorders - here an example of Crohn's Disease: https://t.co/w1Wbevxjzk , which is also the show-case of our pGWAS https://t.co/Yk1uv1O106
@minouye271 This is Supp Fig 3 of https://t.co/mvHiPX9GaE ... what you see are the SNP-protein associations and the GGM edges of that study. Interestingly, there are three signals with different associating proteins, two are with blood group determining SN
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: @PastelBio @jochwenk @neely615 @ProteomicsNews There are a few things that are quite incorrect in this @SomaLogic review: For i…
RT @ksuhre: @PastelBio @jochwenk @neely615 @ProteomicsNews There are a few things that are quite incorrect in this @SomaLogic review: For i…
RT @ksuhre: @PastelBio @jochwenk @neely615 @ProteomicsNews There are a few things that are quite incorrect in this @SomaLogic review: For i…
@PastelBio @jochwenk @neely615 @ProteomicsNews There are a few things that are quite incorrect in this @SomaLogic review: For instance: "32% of aptamers display altered binding affinity attributable to SNP" - THIS IS WRONG - 32% have a cis-pQTL - had they
RT @ksuhre: 200,000 samples awaiting #metabolomics and #proteomics measurements - build on KORA experience with @Biocrates_ https://t.co/Tx…
200,000 samples awaiting #metabolomics and #proteomics measurements - build on KORA experience with @Biocrates_ https://t.co/TxJPBECuvi, @Metabolon https://t.co/AmJXOJpPhE, @Chenomx https://t.co/V8yf7RflA7, numares https://t.co/M1YgvgjDHr, @SomaLogic https
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @Eva3034385615: Love graphical representation of data https://t.co/1qDu1dB7bD
Love graphical representation of data
@DPosthu Here are summary stats for another 1,000 traits: https://t.co/mrO66aLRoU ... see https://t.co/waPATPclZD for details, or https://t.co/uFIB3hCKSf
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
RT @ksuhre: Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of…
Review on a decade in psychiatric GWAS research https://t.co/TJmbGQ2aqn - provides a nice SNP-phenotype network - reminds me of Shin et al. "Atlas of genetic influences on human metabolomics" https://t.co/m1yA6BkMla and our recent #proteomics GWAS https://
Global analysis of A-to-I RNA editing reveals association with common disease variants https://t.co/VM0lPU0Eqp ... interesting overlap with #Parkinsons risk SNP rs3947, which is also a pQTL https://t.co/AqH5PCLShh in our pGWAS https://t.co/mvHiPXrh2c
RT @ksuhre: Stability and reproducibility of proteomic profiles measured with an aptamer-based platform demonstrates the feasibility of SOM…
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform demonstrates the feasibility of SOMAscan for analyses of archived plasma samples https://t.co/3kYezNJ7tG ... here a @SomaLogic pGWAS with ten year old samples http
RT @ksuhre: Be the first to the the next big story in #proteomics, by @aidanbutty and colleagues at @CAMBRIDGE_CEU of @Cambridge_Uni: https…
RT @ksuhre: Be the first to the the next big story in #proteomics, by @aidanbutty and colleagues at @CAMBRIDGE_CEU of @Cambridge_Uni: https…
RT @ksuhre: Be the first to the the next big story in #proteomics, by @aidanbutty and colleagues at @CAMBRIDGE_CEU of @Cambridge_Uni: https…
RT @ksuhre: Be the first to the the next big story in #proteomics, by @aidanbutty and colleagues at @CAMBRIDGE_CEU of @Cambridge_Uni: https…
Be the first to the the next big story in #proteomics, by @aidanbutty and colleagues at @CAMBRIDGE_CEU of @Cambridge_Uni: https://t.co/S8z9H7nGtj - This paper describes 1,927 genetic associations with 1,478 proteins, a fourfold increase over our previous #
RT @ksuhre: ... and complement by checking out Fig 1c in https://t.co/mvHiPXrh2c and https://t.co/waPATPtWRb https://t.co/WjgultyMCv
... and complement by checking out Fig 1c in https://t.co/mvHiPXrh2c and https://t.co/waPATPtWRb https://t.co/WjgultyMCv
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
RT @ksuhre: Our paper "Connecting #genetic risk to #disease end points through the human blood plasma #proteome" is out 😉 #GWAS https://t.c…
@LabExMI @NatImmunol @Etienne_Patin @QuintanaMurci @darragh_duffy @vrouilly @jacquesfellay @christianhammer @C_Alanio @MagnusFontes Great paper! Check out the two attached regional association plots for the SELL locus - nearly identical genetic signal for
RT @ksuhre: Lancet review on global kidney health: a roadmap for closing gaps in care, research, and policy https://t.co/g5Ri0hXAFN highlig…
RT @ksuhre: Lancet review on global kidney health: a roadmap for closing gaps in care, research, and policy https://t.co/g5Ri0hXAFN highlig…
RT @ksuhre: Lancet review on global kidney health: a roadmap for closing gaps in care, research, and policy https://t.co/g5Ri0hXAFN highlig…