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Pharmacogenetics of anti-cancer drugs: State of the art and implementation – recommendations of the French National Network of Pharmacogenetics

Overview of attention for article published in Therapie, April 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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14 Dimensions

Readers on

mendeley
29 Mendeley
Title
Pharmacogenetics of anti-cancer drugs: State of the art and implementation – recommendations of the French National Network of Pharmacogenetics
Published in
Therapie, April 2017
DOI 10.1016/j.therap.2017.01.005
Pubmed ID
Authors

Sylvie Quaranta, Fabienne Thomas

Abstract

Individualized treatment is of special importance in oncology because the drugs used for chemotherapy have a very narrow therapeutic index. Pharmacogenetics may contribute substantially to clinical routine for optimizing cancer treatment to limit toxic effects while maintaining efficacy. This review presents the usefulness of pharmacogenetic tests for some key applications: dihydropyrimidine dehydrogenase (DPYD) genotyping for fluoropyrimidine (5-fluorouracil, capecitabine), UDP glucuronosylstransferase (UGT1A1) for irinotecan and thiopurine S-methyltransferase (TPMT) for thiopurine drugs. Depending on the level of evidence, the French National Network of Pharmacogenetics (RNPGx) has issued three levels of recommendations for these pharmacogenetic tests: essential, advisable, and potentially useful. Other applications, for which the level of evidence is still discussed, will be evoked in the final section of this review.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 24%
Student > Ph. D. Student 4 14%
Student > Postgraduate 4 14%
Other 4 14%
Student > Master 4 14%
Other 4 14%
Unknown 2 7%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 16 55%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 2 7%
Business, Management and Accounting 1 3%
Agricultural and Biological Sciences 1 3%
Other 2 7%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2017.
All research outputs
#8,969,454
of 15,624,287 outputs
Outputs from Therapie
#156
of 322 outputs
Outputs of similar age
#166,231
of 357,304 outputs
Outputs of similar age from Therapie
#7
of 10 outputs
Altmetric has tracked 15,624,287 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 322 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,304 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.