↓ Skip to main content

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

Overview of attention for article published in Emerging Infectious Diseases, February 2017
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
3 news outlets
blogs
2 blogs
twitter
2 tweeters

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
40 Mendeley
Title
Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity
Published in
Emerging Infectious Diseases, February 2017
DOI 10.3201/eid2302.161072
Pubmed ID
Authors

Hongbo Guo, Erik de Vries, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, Cornelis A.M. de Haan

Abstract

Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. H5N8 and H5N2 viruses have caused major economic losses in the poultry industry in Europe and North America, and lethal human infections with H5N6 virus have occurred in Asia. Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. We report that emergence of these viruses is accompanied by a change in receptor-binding specificity. In contrast to ancestral clade 2.3.4 H5 proteins, novel clade 2.3.4.4 H5 proteins bind to fucosylated sialosides because of substitutions K222Q and S227R, which are unique for highly pathogenic influenza virus H5 proteins. North American clade 2.3.4.4 virus isolates have retained only the K222Q substitution but still bind fucosylated sialosides. Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 23%
Student > Master 7 18%
Student > Ph. D. Student 6 15%
Student > Bachelor 5 13%
Student > Doctoral Student 2 5%
Other 4 10%
Unknown 7 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 33%
Biochemistry, Genetics and Molecular Biology 9 23%
Veterinary Science and Veterinary Medicine 6 15%
Immunology and Microbiology 1 3%
Decision Sciences 1 3%
Other 2 5%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2017.
All research outputs
#558,177
of 14,123,042 outputs
Outputs from Emerging Infectious Diseases
#516
of 6,898 outputs
Outputs of similar age
#22,576
of 379,688 outputs
Outputs of similar age from Emerging Infectious Diseases
#17
of 137 outputs
Altmetric has tracked 14,123,042 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,898 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 379,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.