Title |
Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity - Volume 23, Number 2—February 2017 - Emerging Infectious Diseases journal - CDC
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Published in |
Emerging Infectious Diseases, February 2017
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DOI | 10.3201/eid2302.161072 |
Pubmed ID | |
Authors |
Hongbo Guo, Erik de Vries, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, Cornelis A.M. de Haan |
Abstract |
Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. H5N8 and H5N2 viruses have caused major economic losses in the poultry industry in Europe and North America, and lethal human infections with H5N6 virus have occurred in Asia. Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. We report that emergence of these viruses is accompanied by a change in receptor-binding specificity. In contrast to ancestral clade 2.3.4 H5 proteins, novel clade 2.3.4.4 H5 proteins bind to fucosylated sialosides because of substitutions K222Q and S227R, which are unique for highly pathogenic influenza virus H5 proteins. North American clade 2.3.4.4 virus isolates have retained only the K222Q substitution but still bind fucosylated sialosides. Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 40% |
Netherlands | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 90% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 23% |
Student > Ph. D. Student | 7 | 13% |
Student > Master | 7 | 13% |
Student > Bachelor | 6 | 11% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 13% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 26% |
Biochemistry, Genetics and Molecular Biology | 11 | 21% |
Veterinary Science and Veterinary Medicine | 7 | 13% |
Immunology and Microbiology | 5 | 9% |
Unspecified | 1 | 2% |
Other | 4 | 8% |
Unknown | 11 | 21% |