| Title |
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
|
|---|---|
| Published in |
Clinical Pharmacology & Therapeutics, January 2013
|
| DOI | 10.1038/clpt.2013.2 |
| Pubmed ID | |
| Authors |
J K Hicks, J J Swen, C F Thorn, K Sangkuhl, E D Kharasch, V L Ellingrod, T C Skaar, D J Müller, A Gaedigk, J C Stingl |
| Abstract |
Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine are demethylated by CYP2C19 to pharmacologically active metabolites. These drugs and their metabolites, along with desipramine and nortriptyline, undergo hydroxylation by CYP2D6 to less active metabolites. Evidence from published literature is presented for CYP2D6 and CYP2C19 genotype-directed dosing of tricyclic antidepressants. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 33% |
| United States | 3 | 33% |
| Canada | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Scientists | 3 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 357 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Unknown | 350 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 55 | 15% |
| Student > Bachelor | 51 | 14% |
| Student > Ph. D. Student | 47 | 13% |
| Student > Master | 44 | 12% |
| Other | 30 | 8% |
| Other | 77 | 22% |
| Unknown | 53 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 99 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 57 | 16% |
| Biochemistry, Genetics and Molecular Biology | 53 | 15% |
| Agricultural and Biological Sciences | 49 | 14% |
| Unspecified | 10 | 3% |
| Other | 30 | 8% |
| Unknown | 59 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#3,027,999
of 26,017,215 outputs
Outputs from Clinical Pharmacology & Therapeutics
#575
of 4,619 outputs
Outputs of similar age
#29,588
of 299,537 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#9
of 48 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,537 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.