@venkmurthy @cecilejanssens @salonium @VPrasadMDMPH @hamandcheese @DrMJoyner @drjohnm @boback @nilanjan10c has published several studies demonstrating how the underlying genetic architecture of a trait/disease determines number of variants needed for predi
@ethanjweiss @skathire @venkmurthy @rwyeh @boback @ginakolata @matthewherper @bnallamo @ProfHayward @cecilejanssens @f2harrell Statistical genetics experts have known for years that genome-wide polygenic scores are >> than use of only a few SNPs. My
RT @skathire: @cecilejanssens @DrKhouryCDC Why using full set of variants more valuable for prediction than limiting to just genome-wide si…
RT @skathire: @cecilejanssens @DrKhouryCDC Why using full set of variants more valuable for prediction than limiting to just genome-wide si…
@cecilejanssens @DrKhouryCDC Why using full set of variants more valuable for prediction than limiting to just genome-wide significant SNPs? Rationale explained by @nilanjan10c here and his simulations showed full set better https://t.co/Lie7aS7YPy &
RT @skathire: @cecilejanssens @minouye271 Of note, these simulations by @nilanjan10c from 5y ago and last year quite prescient. https://t.c…
@cecilejanssens @minouye271 Of note, these simulations by @nilanjan10c from 5y ago and last year quite prescient. https://t.co/oZ6rK4MUSv https://t.co/6mciuz946f These predictions are exactly what we are seeing with real-world data for a range of diseas
The combination of many modest effects can have a meaningful impact. http://t.co/DsXjHWmzMn @moorejh #GWAS
The combination of many modest effects can have a meaningful impact. http://t.co/DsXjHWmzMn @moorejh #GWAS
The combination of many modest effects can have a meaningful impact. http://t.co/DsXjHWmzMn @moorejh #GWAS
The combination of many modest effects can have a meaningful impact. http://t.co/DsXjHWmzMn @moorejh #GWAS
The combination of many modest effects can have a meaningful impact. http://t.co/DsXjHWmzMn @moorejh #GWAS
Theoretical estimation of predictive ability for human common diseases from current genetic discoveries. http://t.co/DGSSpdd54c
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies http://t.co/RoZFpo9e6z
Projecting the performance of risk prediction based on polygenic analyses of GWAS http://t.co/8TX5RUse8t Nature Genetics
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies = http://t.co/x6p5NX7IjB