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The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer

Overview of attention for article published in The Journal of Molecular Diagnostics, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 821)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
64 news outlets
twitter
19 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
78 Mendeley
Title
The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer
Published in
The Journal of Molecular Diagnostics, September 2016
DOI 10.1016/j.jmoldx.2016.05.007
Pubmed ID
Authors

Loren Joseph, Milena Cankovic, Samuel Caughron, Pranil Chandra, Rajyasree Emmadi, Jill Hagenkord, Stephanie Hallam, Kay E. Jewell, Roger D. Klein, Victoria M. Pratt, Paul G. Rothberg, Robyn L. Temple-Smolkin, Elaine Lyon

Abstract

Clinical utility describes the benefits of each laboratory test for that patient. Many stakeholders have adopted narrow definitions for the clinical utility of molecular testing as applied to targeted pharmacotherapy in oncology, regardless of the population tested or the purpose of the testing. This definition does not address all of the important applications of molecular diagnostic testing. Definitions consistent with a patient-centered approach emphasize and recognize that a clinical test result's utility depends on the context in which it is used and are particularly relevant to molecular diagnostic testing because of the nature of the information they provide. Debates surrounding levels and types of evidence needed to properly evaluate the clinical value of molecular diagnostics are increasingly important because the growing body of knowledge, stemming from the increase of genomic medicine, provides many new opportunities for molecular testing to improve health care. We address the challenges in defining the clinical utility of molecular diagnostics for inherited diseases or cancer and provide assessment recommendations. Starting with a modified analytic validity, clinical validity, clinical utility, and ethical, legal, and social implications model for addressing clinical utility of molecular diagnostics with a variety of testing purposes, we recommend promotion of patient-centered definitions of clinical utility that appropriately recognize the valuable contribution of molecular diagnostic testing to improve patient care.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 77 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 27%
Other 19 24%
Student > Ph. D. Student 7 9%
Student > Master 5 6%
Student > Bachelor 5 6%
Other 12 15%
Unknown 9 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 33%
Medicine and Dentistry 23 29%
Agricultural and Biological Sciences 13 17%
Engineering 2 3%
Computer Science 1 1%
Other 5 6%
Unknown 8 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 513. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2018.
All research outputs
#16,120
of 13,710,419 outputs
Outputs from The Journal of Molecular Diagnostics
#3
of 821 outputs
Outputs of similar age
#784
of 263,735 outputs
Outputs of similar age from The Journal of Molecular Diagnostics
#1
of 15 outputs
Altmetric has tracked 13,710,419 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 821 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,735 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.